Recombinant Proteins
Product List
MOG
Myelin Oligodendrocyte Glycoprotein
Myelin Oligodendrocyte Glycoprotein is a single, non-glycosylated polypeptide chain containing 21 amino acids and having a molecular mass of 2581 Dalton, the molecular formula: C118H177N35O29S.
MOG Human
Myelin Oligodendrocyte Glycoprotein Human Recombinant
MPZL1 Human
Myelin Protein Zero-Like 1 Human Recombinant
OMG Human
Oligodendrocyte Myelin Glycoprotein Recombinant Human
OMG is fused to 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Introduction
Myelin Oligodendrocyte Glycoprotein (MOG) is a glycoprotein that is part of the myelin sheath, which insulates nerve fibers in the central nervous system (CNS). It is encoded by the MOG gene located on chromosome 6 in humans . MOG is a member of the immunoglobulin superfamily and is expressed on the outermost surface of myelin sheaths and oligodendrocyte membranes .
Key Biological Properties: MOG is believed to play a crucial role in the myelination of nerves in the CNS. It is speculated to serve as an adhesion molecule, providing structural integrity to the myelin sheath .
Expression Patterns: MOG is expressed late in the development of oligodendrocytes and is found on the outermost surface of myelin sheaths .
Tissue Distribution: MOG is uniquely expressed in oligodendrocyte membranes and myelin sheaths in the CNS . It is found in various regions of the brain, including the substantia nigra, hippocampus, putamen, and corpus callosum .
Primary Biological Functions: MOG is thought to function as a cellular adhesive molecule, a regulator of oligodendrocyte microtubule stability, and a mediator of interactions between myelin and the immune system .
Role in Immune Responses: MOG is a potential target of cellular and humoral immune responses in inflammatory demyelinating diseases . It is involved in the regulation of immune responses and the T cell receptor signaling pathway .
Pathogen Recognition: MOG has been implicated as a receptor for various pathogens, including viruses .
Mechanisms with Other Molecules and Cells: MOG interacts with other molecules and cells through its role as an adhesion molecule and its involvement in immune interactions .
Binding Partners: MOG binds to various immune molecules, including antibodies, which can lead to immune-mediated demyelination .
Downstream Signaling Cascades: MOG is involved in downstream signaling cascades that regulate immune responses and cell adhesion .
Biomedical Research: MOG is used as a model antigen in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS) .
Diagnostic Tools: MOG antibodies are used as biomarkers for diagnosing MOG antibody-associated disease (MOGAD), a distinct CNS demyelinating disease .
Therapeutic Strategies: Targeting MOG and its antibodies is being explored as a potential therapeutic strategy for treating demyelinating diseases .
Development: MOG is expressed late in the development of oligodendrocytes and is essential for the maturation of these cells .
Aging and Disease: MOG plays a role in maintaining the integrity of the myelin sheath throughout life. Its dysfunction is associated with various demyelinating diseases, including multiple sclerosis and MOGAD .
