MPZL1 Human
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Description
Product Specs
MGSSHHHHHH SSGLVPRGSH MGSLEVYTPK EIFVANGTQG KLTCKFKSTS TTGGLTSVSW SFQPEGADTT VSFFHYSQGQ VYLGNYPPFK DRISWAGDLD KKDASINIEN MQFIHNGTYI CDVKNPPDIV VQPGHIRLYV VEKENLPV.
Product Science Overview
Myelin Protein Zero-Like 1 (MPZL1) is a protein encoded by the MPZL1 gene in humans. This protein is part of the immunoglobulin superfamily and is involved in cell-cell signaling and transmembrane receptor protein tyrosine kinase signaling pathways . MPZL1 is also known by several other names, including Protein Zero-Related (PZR) and Immunoglobulin Family Transmembrane Protein 3 .
MPZL1 plays a crucial role in cellular signaling processes. It acts as a cell surface receptor involved in signal transduction, recruiting PTPN11/SHP-2 to the cell membrane and serving as a substrate for PTPN11/SHP-2 . This protein is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which likely includes Src family tyrosine-protein kinases . Additionally, MPZL1 is implicated in the regulation of integrin-mediated cell motility, particularly through its isoform 1 .
Mutations or dysregulation of the MPZL1 gene have been associated with several diseases, including Intellectual Developmental Disorder, Autosomal Recessive 12, and Leber Congenital Amaurosis 19 . These associations highlight the importance of MPZL1 in normal cellular functions and its potential role in various pathological conditions.
Recombinant Human Myelin Protein Zero-Like 1 is a human full-length protein expressed in wheat germ. It is suitable for various applications, including SDS-PAGE, ELISA, and Western Blotting (WB) . This recombinant protein is used in research to study the functions and interactions of MPZL1, providing insights into its role in cellular signaling and disease mechanisms.
