Recombinant Proteins
Product List
MORF4L1 Human
Mortality Factor 4 Like 1 Human Recombinant
MORF4L1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MORF4L2 Human
Mortality Factor 4 Like 2 Human Recombinant
MORF4L2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-288 a.a.) and having a molecular mass of 34.4kDa (Molecular weight on SDS-PAGE will appear higher).
MORF4L2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Mortality Factor, also known as Mortality Factor 4-like protein 1 (MORF4L1), is a member of the MRG (MORF-related gene) family of transcription factor-like genes. This family includes several members, but only a few, such as MORF4, MRG15/MORF4L1, and MRGX/MORF4L2, are efficiently transcribed and expressed . Mortality Factor is recognized for its role in cellular aging and is classified based on its genetic and functional characteristics.
Key Biological Properties: Mortality Factor is evolutionarily conserved and ubiquitously expressed in mammalian tissues and cells. It plays vital regulatory roles in DNA damage repair, cell proliferation, cellular senescence, and apoptosis .
Expression Patterns: Mortality Factor is expressed in various tissues, with the highest expression observed in the testis. It is also present in more than twenty species, from yeast to humans, indicating its essential role in biological processes .
Tissue Distribution: Mortality Factor is widely distributed across different tissues, with significant expression in the testis, liver, and other vital organs .
Primary Biological Functions: Mortality Factor is involved in regulating gene activation and repression through its interactions with specific histone acetyltransferase and histone deacetylase complexes. It plays a crucial role in DNA damage repair, cell proliferation, cellular senescence, and apoptosis .
Role in Immune Responses and Pathogen Recognition: Mortality Factor contributes to the immune response by regulating the expression of genes involved in pathogen recognition and immune signaling pathways .
Mechanisms with Other Molecules and Cells: Mortality Factor interacts with various cofactors, including histone acetyltransferase and histone deacetylase complexes, to regulate gene expression. These interactions are mediated by its unique N-terminal chromodomain and C-terminal MRG domain .
Binding Partners and Downstream Signaling Cascades: Mortality Factor binds to specific histone modifications and recruits other proteins to form complexes that modulate chromatin structure and gene expression. This regulation affects downstream signaling cascades involved in cell cycle control, DNA repair, and apoptosis .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of Mortality Factor are regulated at multiple levels, including transcriptional regulation and post-translational modifications .
Transcriptional Regulation: Mortality Factor expression is controlled by various transcription factors and regulatory elements in its promoter region .
Post-Translational Modifications: Mortality Factor undergoes several post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, which modulate its stability, localization, and activity .
Biomedical Research: Mortality Factor is a valuable tool in studying cellular aging, DNA damage repair, and gene regulation. Its role in these processes makes it a target for research on aging and age-related diseases .
Diagnostic Tools: Mortality Factor can serve as a biomarker for cellular senescence and aging-related conditions. Its expression levels can be used to assess the aging status of cells and tissues .
Therapeutic Strategies: Targeting Mortality Factor and its regulatory pathways offers potential therapeutic strategies for age-related diseases, cancer, and other conditions involving dysregulated cell proliferation and apoptosis .
Role Throughout the Life Cycle: Mortality Factor plays a critical role throughout the life cycle, from development to aging and disease. During development, it regulates cell proliferation and differentiation. In adulthood, it maintains tissue homeostasis by controlling cell cycle progression and DNA repair. As organisms age, Mortality Factor’s role in cellular senescence and apoptosis becomes more prominent, contributing to the aging process and the development of age-related diseases .
