Recombinant Proteins
Product List
RAET1E Human, IgG-His
Retinoic Acid Early Transcript 1E Human Recombinant, IgG-His Tag
RAET1E Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 437 amino acids (31-225 a.a.) and having a molecular mass of 49.6kDa (Molecular size on SDS-PAGE will appear at approximately 57-70kDa).
RAET1E is expressed with a 239 amino acids IgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
RAET1E Human, Sf9
Retinoic Acid Early Transcript 1E Human Recombinant, Sf9
RAET1E Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 204 amino acids (31-225 a.a.) and having a molecular mass of 23.4kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).
RAET1E is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
RAET1E Human
Retinoic Acid Early Transcript 1E Human Recombinant
RAET1E is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RAET1E Mouse
Retinoic Acid Early Transcript 1E Mouse Recombinant
RAET1E is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
RAET1G Human
Retinoic Acid Early Transcript 1G Human Recombinant
RAET1L Human
Retinoic Acid Early Transcript 1L Human Recombinant
RAET1L Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 202 amino acids (26-218 a.a) and having a molecular mass of 22.9kDa.
RAET1L is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Sterile filtered colorless solution.
Introduction
Retinoic Acid Early Transcript 1E (RAET1E) is a cell surface glycoprotein encoded by the RAET1E gene located on chromosome 6 . RAET1E is related to MHC class I molecules but maps outside the MHC locus . It is composed of an external α1α2 domain, a transmembrane segment, and a C-terminal cytoplasmic tail .
Key Biological Properties: RAET1E functions as a stress-induced ligand for the NKG2D receptor . It is involved in immune responses and pathogen recognition.
Expression Patterns and Tissue Distribution: RAET1E is expressed in various tissues, including the mucosa of the esophagus, skin, testicles, olfactory zone of the nasal mucosa, Achilles tendon, tonsils, and gonads .
Primary Biological Functions: RAET1E plays a crucial role in immune responses by acting as a ligand for the NKG2D receptor, which is involved in natural killer (NK) cell-mediated cytotoxicity . It helps in the recognition and elimination of stressed or infected cells.
Role in Immune Responses and Pathogen Recognition: RAET1E is upregulated in response to cellular stress and infection, facilitating the activation of NK cells and T cells to target and destroy abnormal cells .
Mechanisms with Other Molecules and Cells: RAET1E interacts with the NKG2D receptor on NK cells and some T cells . This interaction triggers the activation of these immune cells, leading to the destruction of target cells.
Binding Partners and Downstream Signaling Cascades: The binding of RAET1E to the NKG2D receptor activates downstream signaling pathways that result in the release of cytotoxic granules and cytokines, promoting the immune response .
Regulatory Mechanisms Controlling Expression and Activity: The expression of RAET1E is regulated by various factors, including stress signals and cytokines . Transcriptional regulation involves the activation of specific transcription factors in response to cellular stress.
Transcriptional Regulation and Post-Translational Modifications: RAET1E expression is modulated at the transcriptional level by stress-induced transcription factors. Post-translational modifications, such as glycosylation, are essential for its proper function and stability .
Biomedical Research: RAET1E is studied for its role in immune responses and its potential as a target for immunotherapy .
Diagnostic Tools: RAET1E expression levels can be used as biomarkers for cellular stress and immune activation .
Therapeutic Strategies: Targeting RAET1E-NKG2D interactions is being explored as a therapeutic strategy for enhancing immune responses against cancer and infections .
Role Throughout the Life Cycle: RAET1E plays a vital role in immune surveillance throughout life. It is involved in the recognition and elimination of stressed or infected cells from development to aging .
From Development to Aging and Disease: RAET1E expression is crucial during development for immune system maturation and continues to be important in maintaining immune homeostasis and responding to infections and cellular stress throughout life .
