RAET1E Mouse

RAET1E is a cell surface glycoprotein composed of an external α1α2 domain, a transmembrane segment, and a C-terminal cytoplasmic tail . Unlike other RAET1 proteins, RAET1E has type I membrane-spanning sequences at its C-terminus rather than glycosylphosphatidylinositol anchor sequences . This protein functions as a ligand for the NKG2D receptor, which is expressed on the surface of several types of immune cells .

The interaction between RAET1E and the NKG2D receptor plays a crucial role in both innate and adaptive immune responses. It mediates natural killer (NK) cell cytotoxicity and T cell-mediated cytotoxicity, contributing to the regulation of immune responses .

RAET1E is expressed in various tissues, including the mucosa of the esophagus, skin, testicles, and olfactory zone of the nasal mucosa . The expression of RAET1E is induced by stress signals, making it a stress-induced ligand for the NKG2D receptor . This stress-induced expression is significant in the context of immune surveillance, where cells under stress, such as those infected by viruses or undergoing transformation, can be targeted by NK cells and cytotoxic T lymphocytes.

The recombinant form of RAET1E, particularly in mouse models, is widely used in research to study its role in immune responses. By using recombinant proteins, researchers can investigate the specific interactions between RAET1E and the NKG2D receptor, as well as the downstream effects on immune cell activation and cytotoxicity. This research is essential for understanding the mechanisms of immune surveillance and developing potential therapeutic strategies for diseases such as cancer and viral infections.

RAET1E has been associated with various diseases, including familial temporal lobe epilepsy . Its role in immune responses also makes it a potential target for immunotherapy. By modulating the interaction between RAET1E and the NKG2D receptor, it may be possible to enhance the immune system’s ability to target and eliminate cancer cells or infected cells.