Recombinant Proteins
Product List
SLC3A2 Human
Solute Carrier Family 3 Member 2 Human Recombinant
SLC3A2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 434 amino acids (206-630a.a.) and having a molecular mass of 47.9kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
SLC3A2 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
SLC51B Human
Solute Carrier Family 51 Beta Human Recombinant
Introduction
The Solute Carrier (SLC) family is a large group of membrane transport proteins that facilitate the transport of a wide variety of substrates across cellular membranes. This family includes over 400 members organized into 66 families . SLC transporters are primarily involved in the uptake of small molecules, including nutrients and xenobiotics, into cells . They are classified based on their sequences, structural features, and biological functions .
Key Biological Properties: SLC transporters are integral membrane proteins that contain multiple hydrophobic transmembrane alpha helices connected by hydrophilic intra- and extracellular loops . They can function as monomers or oligomers .
Expression Patterns and Tissue Distribution: SLC transporters are expressed in various tissues and cells, including the cell membrane, mitochondria, and other intracellular organelles . They are found in both prokaryotes and eukaryotes .
Primary Biological Functions: SLC transporters are responsible for transporting a broad spectrum of substrates such as neurotransmitters, amino acids, lipids, ions, and drugs across cellular membranes . They play a crucial role in maintaining cellular homeostasis and metabolic processes .
Role in Immune Responses and Pathogen Recognition: Some SLC transporters are involved in immune responses by regulating the transport of essential nutrients and metabolites required for immune cell function . They also play a role in pathogen recognition by modulating the transport of molecules involved in immune signaling .
Mechanisms with Other Molecules and Cells: SLC transporters function as facilitative transporters, allowing solutes to flow downhill with their electrochemical gradients, or as secondary active transporters, allowing solutes to flow uphill against their electrochemical gradient by coupling their transport to the movement of a second solute .
Binding Partners and Downstream Signaling Cascades: SLC transporters interact with various binding partners, including other transporters, receptors, and signaling molecules, to regulate their activity and downstream signaling pathways .
Regulatory Mechanisms: The expression and activity of SLC transporters are regulated by various mechanisms, including transcriptional regulation, post-translational modifications, and feedback inhibition . These regulatory mechanisms ensure the proper functioning of SLC transporters in response to cellular and environmental changes .
Biomedical Research: SLC transporters are attractive targets for drug discovery and development due to their role in transporting drugs and other therapeutic agents across cellular membranes . They are also used as biomarkers for various diseases and conditions .
Diagnostic Tools and Therapeutic Strategies: SLC transporters are used in diagnostic tools to detect and monitor diseases, such as cancer and metabolic disorders . They are also targeted in therapeutic strategies to modulate their activity and improve drug efficacy and safety .
Role Throughout the Life Cycle: SLC transporters play a critical role throughout the life cycle, from development to aging and disease . They are involved in various developmental processes, including cell differentiation and organogenesis . Dysregulation of SLC transporters can lead to various diseases, including neurological disorders, metabolic disorders, and cancer .
