SLC3A2 Human
Sf9, Baculovirus cells.
Solute Carrier Family 3 Member 2, Lymphocyte Activation Antigen 4F2 Large Subunit, Solute Carrier Family 3 (Activators Of Dibasic And Neutral Amino Acid Transport), Member 2, Antigen Identified By Monoclonal Antibodies 4F2, TRA1.10, TROP4, And T43, Solute Carrier Family 3 (Amino Acid Transporter Heavy Chain), Member 2, 4F2 Cell-Surface Antigen Heavy Chain, Monoclonal Antibody 44D7, CD98 Heavy Chain, 4F2HC, MDU1, Antigen Defined By Monoclonal Antibody 4F2, Heavy Chain, Antigen Defined By Monoclonal Antibody 4F2, 4F2 Heavy Chain Antigen, 4F2 Heavy Chain, CD98 Antigen, Heavy Chain, CD98HC, 4T2HC, NACAE, CD98, 4F2, 4F2 cell-surface antigen heavy chain.
Greater than 95.0% as determined by SDS-PAGE.
Description
SLC3A2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 434 amino acids (206-630a.a.) and having a molecular mass of 47.9kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
SLC3A2 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
SLC3A2, alternatively known as Solute Carrier Family 3 Member 2, is a single-pass type II membrane protein classified as a member of the SLC3A transporter family. This protein is ubiquitously expressed across various tissues, with the highest expression levels observed in the kidney, placenta, and testis, and the lowest expression in the thymus. SLC3A2 plays a critical role in the functionality of light chain amino-acid transporters, facilitating the sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine, and tryptophan. Moreover, SLC3A2 is involved in the cellular trafficking and targeting of LAT1 and LAT2 to the plasma membrane.
Produced in Sf9 Baculovirus cells, SLC3A2 is a single, glycosylated polypeptide chain comprising 434 amino acids (206-630a.a.). It has a molecular weight of 47.9kDa, although its apparent size on SDS-PAGE may range from approximately 40-57kDa.
This protein is expressed with a C-terminal 6 amino acid His tag and purified using proprietary chromatographic techniques.
The SLC3A2 protein solution is provided at a concentration of 0.5mg/ml in Phosphate Buffered Saline (pH 7.4) with 10% glycerol.
For extended storage, freezing at -20°C is recommended.
To ensure stability during long-term storage, adding a carrier protein (0.1% HSA or BSA) is advised.
Repeated freeze-thaw cycles should be avoided.
The purity of SLC3A2 is determined to be greater than 95.0% by SDS-PAGE analysis.
Solute Carrier Family 3 Member 2, Lymphocyte Activation Antigen 4F2 Large Subunit, Solute Carrier Family 3 (Activators Of Dibasic And Neutral Amino Acid Transport), Member 2, Antigen Identified By Monoclonal Antibodies 4F2, TRA1.10, TROP4, And T43, Solute Carrier Family 3 (Amino Acid Transporter Heavy Chain), Member 2, 4F2 Cell-Surface Antigen Heavy Chain, Monoclonal Antibody 44D7, CD98 Heavy Chain, 4F2HC, MDU1, Antigen Defined By Monoclonal Antibody 4F2, Heavy Chain, Antigen Defined By Monoclonal Antibody 4F2, 4F2 Heavy Chain Antigen, 4F2 Heavy Chain, CD98 Antigen, Heavy Chain, CD98HC, 4T2HC, NACAE, CD98, 4F2, 4F2 cell-surface antigen heavy chain.
Sf9, Baculovirus cells.
ADPRAPRCRE LPAQKWWHTG ALYRIGDLQA FQGHGAGNLA GLKGRLDYLS SLKVKGLVLG PIHKNQKDDV AQTDLLQIDP NFGSKEDFDS LLQSAKKKSI RVILDLTPNY RGENSWFSTQ VDTVATKVKD ALEFWLQAGV DGFQVRDIEN LKDASSFLAE WQNITKGFSE DRLLIAGTNS SDLQQILSLL ESNKDLLLTS SYLSDSGSTG EHTKSLVTQY LNATGNRWCS WSLSQARLLT SFLPAQLLRL YQLMLFTLPG TPVFSYGDEI GLDAAALPGQ PMEAPVMLWD ESSFPDIPGA VSANMTVKGQ SEDPGSLLSL FRRLSDQRSK ERSLLHGDFH AFSAGPGLFS YIRHWDQNER FLVVLNFGDV GLSAGLQASD LPASASLPAK ADLLLSTQPG REEGSPLELE RLKLEPHEGL LLRFPYAAHH HHHH.
Product Science Overview
SLC3A2 encodes a cell surface, transmembrane protein that exists as the heavy chain of a heterodimer. It is covalently bound through disulfide bonds to one of several possible light chains from the SLC7 family of transporters . These heterodimers function as amino acid transporters, facilitating the transport of L-type amino acids across the plasma membrane .
The protein encoded by SLC3A2 acts as a chaperone, aiding in the biogenesis and trafficking of functional transporter heterodimers to the plasma membrane . This process is essential for maintaining proper cellular function and homeostasis.
SLC3A2 is involved in several critical biological processes, including the regulation of intracellular calcium levels and the transport of neutral L-amino acids . It plays a significant role in various physiological pathways, such as the transport of inorganic cations/anions and amino acids/oligopeptides, as well as proximal tubule transport .
Human recombinant SLC3A2 is used in research to study its function and role in various diseases. Recombinant proteins are produced through genetic engineering techniques, allowing scientists to investigate the protein’s structure, function, and interactions in a controlled environment.
