Recombinant Proteins
Product List
SOX2 Human
SRY (sex determining region Y)-box 2 Human Recombinant
SOX2 Human, PolyR
SRY (sex determining region Y)-box 2 Human Recombinant, Polyarginine-Tag
The SOX2 is fused to a C-terminal poly-arginine tag and purified by proprietary chromatographic techniques.
SOX2 Human, TAT
SRY (sex determining region Y)-box 2 Human Recombinant, TAT
Sox2 is fused to a 13 amino acid TAT peptide at C-terminus (GGYGRKKRRQRRR) & purified by proprietary chromatographic techniques.
Introduction
The Sex Determining Region Y (SRY) gene, also known as the SRY-box, is a gene located on the Y chromosome that is crucial for the development of male phenotypes in mammals. It is classified as a transcription factor, specifically a member of the high-mobility group (HMG)-box family of DNA-binding proteins .
Key Biological Properties: The SRY gene encodes a protein that binds to specific DNA sequences, bending the DNA and facilitating the transcription of other genes necessary for male development .
Expression Patterns: SRY is expressed during a critical window in embryonic development, specifically in the bipotential gonads, which can develop into either testes or ovaries .
Tissue Distribution: The expression of SRY is primarily restricted to the developing gonads, where it initiates the formation of testes .
Primary Biological Functions: The primary function of the SRY gene is to trigger the development of male characteristics by initiating the formation of testes. This process involves the differentiation of Sertoli cells, which support and nourish developing sperm cells .
Role in Immune Responses and Pathogen Recognition: While SRY is not directly involved in immune responses or pathogen recognition, its role in sex determination can indirectly influence immune system development and function, as there are differences in immune responses between males and females .
Mechanisms with Other Molecules and Cells: The SRY protein interacts with other transcription factors and co-factors to regulate gene expression. It binds to specific DNA sequences, bending the DNA and facilitating the transcription of target genes .
Binding Partners: SRY interacts with various proteins, including SOX9, another transcription factor critical for testis development .
Downstream Signaling Cascades: The activation of SRY leads to the upregulation of genes involved in testis formation, such as SOX9, which further activates other genes necessary for male development .
Transcriptional Regulation: The expression of SRY is tightly regulated at the transcriptional level, with specific enhancers and promoters controlling its activity .
Post-Translational Modifications: SRY undergoes various post-translational modifications, such as phosphorylation, which can influence its stability and DNA-binding activity .
Biomedical Research: SRY is a critical gene in the study of sex determination and differentiation. Understanding its function and regulation can provide insights into disorders of sex development (DSDs) and other related conditions .
Diagnostic Tools: SRY is used as a marker in genetic testing to determine the presence of the Y chromosome, which can be important in diagnosing certain genetic conditions .
Therapeutic Strategies: While direct therapeutic applications of SRY are limited, understanding its role in sex determination can inform treatments for DSDs and other conditions related to sex chromosome abnormalities .
Development: SRY plays a crucial role in the early stages of embryonic development by initiating the formation of testes and subsequent male differentiation .
Aging and Disease: While SRY’s primary role is in early development, its influence can extend into later stages of life. Abnormalities in SRY function or expression can lead to various disorders of sex development and other health issues .
