SOX2 Human, TAT
Description
Sox2 is fused to a 13 amino acid TAT peptide at C-terminus (GGYGRKKRRQRRR) & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The SRY (Sex Determining Region Y)-Box 2 is a crucial gene located on the Y chromosome, playing a pivotal role in male sex determination in mammals. This gene encodes a transcription factor that initiates the development of male characteristics by triggering the differentiation of the bipotential gonad into testes.
The SRY gene was first identified in 1990 by a team of researchers led by Peter Koopman . It is located on the short arm of the Y chromosome and is responsible for initiating the male sex determination pathway. The SRY protein, produced by this gene, binds to specific DNA sequences and regulates the expression of other genes involved in testis development .
The SRY protein functions as a transcription factor, meaning it binds to DNA and influences the transcription of other genes. One of the primary targets of SRY is the SOX9 gene, which is crucial for the development of Sertoli cells in the testes. Sertoli cells support and nourish the developing sperm cells and are essential for proper testis formation .
The term “Human Recombinant, TAT” refers to a recombinant form of the SRY protein that has been engineered for research purposes. The TAT (Trans-Activator of Transcription) sequence is often fused to proteins to facilitate their entry into cells. This allows researchers to study the function of the SRY protein in various cellular contexts and understand its role in sex determination more comprehensively.
Recombinant SRY proteins are invaluable tools in genetic and developmental biology research. They help scientists investigate the molecular mechanisms underlying sex determination and the development of sexual characteristics. By studying the interactions between SRY and other genes, researchers can gain insights into disorders of sex development (DSDs) and potential therapeutic approaches .
