Recombinant Proteins
Product List
FOLR1 Human
Folate Receptor 1 Human Recombinant
FOLR1 Human, Sf9
Folate Receptor 1 Human Recombinant, sf9
FOLR1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 218 amino acids (26-234a.a.) and having a molecular mass of 25.6kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).
FOLR1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
FOLR2 Human
Folate Receptor 2 Human Recombinant
FOLR2 Human Recombinant is a single, glycosylated polypeptide chain containing 215 amino acids (22-230a.a) and having a molecular mass of 25.1kDa. FOLR2 is fused to a 6 a.a His tag at C-terminal, and is purified by proprietary chromatographic techniques.
Introduction
The folate receptor (FR) is a cell surface glycoprotein that binds folate and its derivatives, facilitating their transport into cells. Folate receptors are crucial for the uptake of folate, which is essential for DNA synthesis, repair, and methylation. There are three main isoforms of folate receptors in humans: FR-α, FR-β, and FR-γ .
Primary Biological Functions: The primary function of folate receptors is to mediate the uptake of folate into cells, which is essential for DNA synthesis, repair, and methylation. Folate is also crucial for cell division and growth .
Role in Immune Responses and Pathogen Recognition: Folate receptors play a role in the immune system by facilitating the uptake of folate in immune cells, which is necessary for their proliferation and function. Additionally, folate receptors are involved in the recognition and binding of certain pathogens, aiding in the immune response .
Mechanisms with Other Molecules and Cells: Folate receptors bind to folate and its derivatives with high affinity. Once bound, the receptor-folate complex is internalized into the cell via receptor-mediated endocytosis .
Binding Partners and Downstream Signaling Cascades: Folate receptors interact with various binding partners, including folate-binding proteins and other cell surface receptors. These interactions can activate downstream signaling pathways, such as the JAK/STAT pathway, which is involved in cell proliferation and survival .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of folate receptors are regulated at multiple levels, including transcriptional and post-translational modifications. Transcriptional regulation involves various transcription factors that bind to the promoter regions of folate receptor genes .
Post-Translational Modifications: Folate receptors undergo several post-translational modifications, such as glycosylation, which are essential for their proper folding, stability, and function .
Biomedical Research: Folate receptors are widely studied in biomedical research due to their role in folate metabolism and their overexpression in certain cancers .
Diagnostic Tools: Folate receptors are used as biomarkers for the diagnosis of various cancers, including ovarian and lung cancer .
Therapeutic Strategies: Folate receptors are targeted in cancer therapy using folate-conjugated drugs and folate receptor-targeted therapies, such as antibody-drug conjugates and chimeric antigen receptor (CAR) T-cell therapies .
Role Throughout the Life Cycle: Folate receptors play a crucial role throughout the life cycle, from development to aging. During fetal development, folate receptors are essential for neural tube formation and preventing neural tube defects . In adults, they are involved in maintaining normal cellular functions and preventing diseases associated with folate deficiency .
Aging and Disease: As individuals age, the efficiency of folate uptake may decline, leading to an increased risk of folate deficiency-related diseases, such as anemia and cognitive decline .
