Recombinant Proteins
Product List
C.Albicans Enolase
Candida Albicans Enolase Recombinant
Recombinant Candida Albicans Enolase produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 46kDa. C.Albicans Enolase is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
C.Albicans PLB1
Candida Albicans Phospholipase B1 Recombinant
Recombinant Candida Albicans Phospholipase B1 (24-526 a.a) produced in E. coli having a Mw of 52kDa. C.Albicans PLB1 is fused to a 6xHis tag at its C terminal is and purified by proprietary chromatographic technique.
Escherichia Coli.
Introduction
Candida albicans is a type of opportunistic pathogenic yeast that is a common member of the human gut flora. It belongs to the kingdom Fungi, division Ascomycota, class Saccharomycetes, order Saccharomycetales, family Saccharomycetaceae, and genus Candida . It is usually a commensal organism but can become pathogenic in immunocompromised individuals .
Key Biological Properties: Candida albicans is a polymorphic fungus, meaning it can grow in several different forms, primarily yeast, pseudohyphae, and hyphae . It is encapsulated, diploid, and can form biofilms .
Expression Patterns and Tissue Distribution: Candida albicans is detected in the gastrointestinal tract and mouth in 40–60% of healthy adults . It can also be found on the skin and in the vagina .
Primary Biological Functions: Candida albicans plays a role in maintaining the balance of the microbiome in healthy individuals. However, it can become pathogenic and cause infections such as thrush, vaginal yeast infections, and invasive candidiasis .
Role in Immune Responses and Pathogen Recognition: Candida albicans has an arsenal of virulence factors that help it evade the immune system and establish infections. These include enzymes that facilitate fungal invasion, fungal-hyphal growth, and biofilm formation .
Mechanisms with Other Molecules and Cells: Candida albicans interacts with host cells through mechanisms such as induced endocytosis and active penetration. The hyphal-associated invasin Als3 triggers uptake by epithelial cells, while hyphal formation is required for active penetration .
Binding Partners and Downstream Signaling Cascades: Farnesol, a quorum-sensing molecule, plays a role in the yeast-to-hyphal transition and can act as a virulence factor during pathogenesis .
Regulatory Mechanisms: The expression and activity of Candida albicans are controlled by several environmental cues that regulate a morphogenetic switch from yeast to filamentous growth. This transition is important for virulence and involves signaling cascades such as cAMP-PKA and MAPK .
Transcriptional Regulation and Post-Translational Modifications: The regulatory pathways that control either the stress response or morphogenesis are required for full virulence and promote survival of Candida albicans in the host .
Biomedical Research: Candida albicans is commonly used as a model organism for studying fungal pathogens .
Diagnostic Tools: Diagnostic tools for Candida albicans infections include culture methods, molecular techniques, and serological tests .
Therapeutic Strategies: Current therapeutic strategies for Candida albicans infections include antifungal medications such as polyenes, azoles, and echinocandins. Nanotechnology is being explored to enhance the efficiency of drug development for Candida albicans infections .
Role Throughout the Life Cycle: Candida albicans has a parasexual life cycle and can switch between different phenotypes. It can grow in three distinct morphologies: yeast, pseudohyphae, and true hyphae . This flexibility allows it to adapt to different environmental conditions and host niches, contributing to its pathogenicity .
