Recombinant Proteins
Product List
LAMP1 Human
Lysosomal-Associated Membrane Protein Human 1 Recombinant
LAMP1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 363 amino acids (29-382a.a.) and having a molecular mass of 39.4kDa. (Molecular size on SDS-PAGE will appear at approximately 57-70kDa).
LAMP1 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Sterile filtered colorless solution.
LAMP2 Mouse
Lysosomal-Associated Membrane Protein 2 Mouse Recombinant
LAMP2 Human
Lysosomal-Associated Membrane Protein 2 Human Recombinant
LAMP3 Human
Lysosomal-Associated Membrane Protein 3 Human Recombinant
Introduction
Lysosomal-Associated Membrane Proteins (LAMPs) are a family of glycoproteins primarily located on the lysosomal membrane. The most well-known members of this family include LAMP-1, LAMP-2, and LAMP-3 (also known as DC-LAMP). These proteins play crucial roles in maintaining lysosomal integrity and function .
Key Biological Properties: LAMPs are highly glycosylated proteins, which protect them from degradation by lysosomal enzymes. They are integral membrane proteins with a large luminal domain and a short cytoplasmic tail .
Expression Patterns: LAMP-1 and LAMP-2 are ubiquitously expressed in various tissues, while LAMP-3 is more specific to dendritic cells .
Tissue Distribution: LAMP-1 and LAMP-2 are found in almost all cell types, with high expression in cells involved in immune responses, such as macrophages and dendritic cells .
Primary Biological Functions: LAMPs are involved in maintaining lysosomal stability, pH regulation, and catabolism. They also play roles in autophagy and phagocytosis .
Role in Immune Responses: LAMPs, particularly LAMP-1 and LAMP-2, are involved in the immune response by participating in antigen presentation and pathogen recognition .
Mechanisms with Other Molecules and Cells: LAMPs interact with various molecules, including selectins and other glycan-binding proteins. These interactions are crucial for lysosomal function and cellular signaling .
Binding Partners: LAMPs bind to carbohydrate ligands, which are essential for their role in immune responses and cellular communication .
Downstream Signaling Cascades: LAMPs are involved in signaling pathways that regulate lysosomal biogenesis, autophagy, and immune responses .
Regulatory Mechanisms: The expression and activity of LAMPs are regulated at multiple levels, including transcriptional regulation and post-translational modifications .
Transcriptional Regulation: LAMP genes are regulated by various transcription factors that respond to cellular stress and nutrient availability .
Post-Translational Modifications: LAMPs undergo extensive glycosylation, which is crucial for their stability and function .
Biomedical Research: LAMPs are used as markers for lysosomal function and integrity in various research studies .
Diagnostic Tools: LAMPs, particularly LAMP-1, are used as biomarkers for lysosomal storage disorders and other diseases .
Therapeutic Strategies: Targeting LAMPs has potential therapeutic applications in treating lysosomal storage disorders and modulating immune responses .
Development to Aging and Disease: LAMPs play essential roles throughout the life cycle, from development to aging. They are involved in cellular homeostasis, development, and aging processes. Dysregulation of LAMPs is associated with various diseases, including neurodegenerative disorders and cancer .
