LAMP3 Human

LAMP3 is a Type I integral membrane protein consisting of approximately 416 amino acid residues, with about 90% of the protein located within the lumen of the lysosomes . It plays a crucial role in the unfolded protein response (UPR), contributing to protein degradation and cell survival during proteasomal dysfunction . Additionally, LAMP3 is involved in the fusion process of lysosomes with autophagosomes, thereby modulating the autophagic process .

LAMP3 is highly expressed in dendritic cells during their differentiation and maturation . During human fetal development, particularly between weeks 10 and 20, LAMP3 is prominently expressed in the lungs . In normal adult tissues, LAMP3 expression is observed in the lungs, appendix, testis, and lymph nodes .

LAMP3 is almost exclusively found in mature dendritic cells, where it aids in the identification and processing of antigens during immune responses . It first appears in the MHC Class II compartment and is linked with the maturation of dendritic cells . LAMP3 also serves as a marker for transformed type II pneumocytes or alveolar cells .

Studies have shown that LAMP3 is associated with the inhibition of viral replication, particularly in Influenza A cells . It supports the FURIN-mediated cleavage of the mumps virus fusion protein F by interacting with both FURIN and the unprocessed form of the viral protein .

Given its significant role in immune responses and viral infections, LAMP3 is a subject of interest in various research studies. Its involvement in the unfolded protein response and autophagic processes also makes it a potential target for therapeutic interventions in diseases related to proteasomal dysfunction and lysosomal storage disorders .