LAMP2 Human
Lysosomal-Associated Membrane Protein 2 Human Recombinant
Cat. No.
BT4240
Source
Sf9 insect cells.
Synonyms
Lysosomal-associated membrane protein 2, CD107b, LAMP-2, CD107 antigen-like family member B, LGP110, LAMP2.
Appearance
Purity
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
LAMP2 is a full-length cDNA coding for the human lysosomal-associated membrane protein 2 having a molecular mass of 42,488 Dalton (pH 5.88). LAMP2 protein is fused to a deca-histidine purification tag.
Product Specs
Introduction
The LAMP2 gene encodes a membrane glycoprotein that is a member of a larger family. This glycoprotein functions by providing carbohydrate ligands to selectins. LAMP2 plays a role in tumor cell metastasis and is also involved in protecting, maintaining, and adhering lysosomes. Alternative splicing of this gene results in multiple transcript variants that encode different protein isoforms.
Description
LAMP2 is a full-length cDNA that encodes the human lysosomal-associated membrane protein 2. This protein has a molecular mass of 42,488 Daltons at a pH of 5.88. A deca-histidine purification tag is fused to the LAMP2 protein.
Formulation
LAMP2 is supplied at a concentration of 0.94 mg/ml in a buffer solution containing 16 mM HEPES (pH 8.0), 130 mM NaCl, and 20% glycerol.
Stability
For optimal storage of LAMP2, it is recommended to keep it at 4°C if the entire vial will be used within 2-4 weeks. For extended storage, the product should be stored frozen at -20°C. To maintain product integrity, avoid repeated freeze-thaw cycles.
Synonyms
Lysosomal-associated membrane protein 2, CD107b, LAMP-2, CD107 antigen-like family member B, LGP110, LAMP2.
Source
Sf9 insect cells.
Product Science Overview
Structure and Function
LAMP2 is an integral membrane protein predominantly found in the lysosomal membrane. It is involved in various cellular processes, including:
- Lysosome Biogenesis: LAMP2 is essential for the formation and maintenance of lysosomes, which are cellular organelles responsible for degrading and recycling cellular waste .
- Lysosomal pH Regulation: It acts as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity .
- Autophagy: LAMP2 plays a critical role in chaperone-mediated autophagy (CMA), a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-life .
Genetic and Molecular Aspects
Clinical Significance
Research and Applications
Recombinant human LAMP2 is used in various research applications to study its function and role in diseases. It is also utilized in the development of therapeutic strategies for conditions associated with lysosomal dysfunction.
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