Recombinant Proteins
Product List
SDC1 Human
Syndecan-1 Human Recombinant
SDC1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SDC2 Human
Syndecan-2 Human Recombinant
SDC2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 135 amino acids (19-144a.a.) and having a molecular mass of 15kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). SDC2 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
SDC4 Human
Syndecan-4 Human Recombinant
SDCBP Human
Syndecan Binding Protein Human Recombinant
SDCBP is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SDCBP2 Human
Syndecan Binding Protein 2 Human Recombinant
Introduction
Syndecans are a family of transmembrane heparan sulfate proteoglycans (HSPGs) that play crucial roles in cell signaling, adhesion, and migration. They are characterized by their single transmembrane domain and the presence of heparan sulfate and chondroitin sulfate chains on their extracellular domain . The syndecan family consists of four members: Syndecan-1, Syndecan-2, Syndecan-3, and Syndecan-4 . These proteins are classified based on their sequence homology and structural features .
Key Biological Properties: Syndecans are involved in various cellular processes, including cell adhesion, migration, and proliferation . They interact with a wide range of ligands, such as growth factors, cytokines, and extracellular matrix proteins .
Expression Patterns: Syndecans are expressed in a tissue-specific manner. For example, Syndecan-1 is predominantly found in epithelial cells, while Syndecan-2 is expressed in fibroblasts and endothelial cells .
Tissue Distribution: Syndecans are distributed across various tissues. Syndecan-1 is primarily located in epithelial tissues, Syndecan-2 in connective tissues, Syndecan-3 in neural tissues, and Syndecan-4 in a variety of tissues, including muscle and skin .
Primary Biological Functions: Syndecans are involved in cell-cell and cell-matrix interactions, which are essential for tissue development and repair . They also play a role in the regulation of cell growth and differentiation .
Role in Immune Responses and Pathogen Recognition: Syndecans participate in immune responses by mediating the interaction between leukocytes and endothelial cells, facilitating leukocyte extravasation . They also bind to pathogens, aiding in their recognition and clearance by the immune system .
Mechanisms with Other Molecules and Cells: Syndecans interact with various molecules, including growth factors, cytokines, and extracellular matrix proteins, through their heparan sulfate chains . These interactions trigger downstream signaling pathways that regulate cellular behavior .
Binding Partners and Downstream Signaling Cascades: Syndecans bind to multiple partners, such as fibroblast growth factors and vascular endothelial growth factor . These interactions activate signaling cascades involving pathways like Wnt, integrin, and receptor tyrosine kinases .
Regulatory Mechanisms: The expression and activity of syndecans are regulated at multiple levels. Transcriptional regulation involves various transcription factors, including Hox and MyoD family members . Post-translational modifications, such as phosphorylation and glycosylation, also play a critical role in modulating syndecan function .
Biomedical Research: Syndecans are studied for their roles in cancer, inflammation, and wound healing . They serve as biomarkers for disease progression and therapeutic targets .
Diagnostic Tools: Syndecan levels can be measured to diagnose and monitor diseases, such as cancer and cardiovascular conditions .
Therapeutic Strategies: Syndecans are targeted in therapies aimed at modulating their interactions with ligands to treat diseases like cancer and fibrosis .
Development to Aging and Disease: Syndecans are involved in various stages of the life cycle. During development, they regulate cell proliferation and differentiation . In adulthood, they maintain tissue homeostasis and repair . Dysregulation of syndecan expression is associated with aging and diseases, such as cancer and neurodegenerative disorders .
