SDCBP2 Human
Description
Product Specs
Product Science Overview
Syndecan Binding Protein 2 (SDCBP2), also known as syntenin-2, is a protein encoded by the SDCBP2 gene in humans. This protein is part of the syndecan family, which are type I transmembrane proteins capable of carrying heparan sulfate (HS) and chondroitin sulfate glycosaminoglycans. Syndecan proteins play crucial roles in cell signaling, cell adhesion, and the organization of the extracellular matrix (ECM).
SDCBP2 contains two class II PDZ domains, which facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins. These PDZ domains are essential for mediating cell signaling and organizing protein complexes. The protein encoded by the SDCBP2 gene binds to phosphatidylinositol 4,5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization, cell division, and cell survival .
Syndecan Binding Protein 2 is involved in various cellular processes, including:
- Cell Signaling: SDCBP2 interacts with other proteins to mediate signaling pathways that regulate cell growth, differentiation, and survival.
- Cell Adhesion: It plays a role in cell-cell and cell-matrix adhesion, which is crucial for maintaining tissue integrity and facilitating cellular communication.
- Extracellular Matrix Organization: SDCBP2 contributes to the organization of the ECM by binding to heparan sulfate proteoglycans, which are essential for the structural integrity of tissues.
Recombinant human SDCBP2 is produced using advanced biotechnological methods. It is typically expressed in a suitable host system, such as E. coli or mammalian cells, and purified to high levels of purity. The recombinant protein retains its functional properties and is used in various research applications, including:
- Functional Studies: Investigating the role of SDCBP2 in cell signaling, adhesion, and ECM organization.
- Drug Development: Screening for potential therapeutic agents that target SDCBP2 interactions.
- Biochemical Assays: Studying the binding properties and interactions of SDCBP2 with other proteins and molecules.
SDCBP2 has been implicated in several diseases and pathological conditions. For example, alterations in SDCBP2 expression or function have been associated with cancer progression, where it may influence tumor cell adhesion, migration, and invasion. Understanding the role of SDCBP2 in these processes can provide insights into potential therapeutic targets for cancer treatment.
