Recombinant Proteins
Product List
AHSG
Alpha-2-HS-Glycoprotein Human
The human Alpha-2-HS-Glycoprotein containing 349 a.a was purified from the human plasma.
The total molecular mass is 37.3kDa (calculated without glycosylation).
AHSG Human
Alpha-2-HS-Glycoprotein Human Recombinant
AHSG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
AHSG Human HEK
Alpha-2-HS-Glycoprotein Human Recombinant HEK
AHSG Mouse
Alpha-2-HS-Glycoprotein Mouse Recombinant
Introduction
Key Biological Properties: AHSG is a negatively charged serum glycoprotein that consists of two polypeptide chains cleaved from a single mRNA . It has a molecular weight of approximately 49,000 Daltons .
Expression Patterns: AHSG is predominantly expressed in the liver and adipose tissues . It is also present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix .
Tissue Distribution: AHSG is found in various tissues, including the liver, gallbladder, fetal liver, hematopoietic progenitor cells, and the choroid plexus .
Primary Biological Functions: AHSG plays a role in endocytosis, brain development, and bone tissue formation . It also has opsonic properties and influences the mineral phase of bone .
Role in Immune Responses and Pathogen Recognition: AHSG is involved in the regulation of inflammatory responses and has been shown to negatively regulate the insulin receptor signaling pathway . It also plays a role in the acute-phase response and neutrophil degranulation .
Mechanisms with Other Molecules and Cells: AHSG interacts with various molecules and cells through its binding partners. It shows affinity for calcium and barium ions, which may influence its role in bone mineralization .
Binding Partners: AHSG can bind multiple ligands, including endopeptidase inhibitors and kinases . It has been identified as a key glycoprotein in exerting cytoprotective activity against oxidative injury in neuronal cells .
Downstream Signaling Cascades: AHSG is involved in several signaling pathways, including the regulation of insulin-like growth factor transport and uptake by insulin-like growth factor binding proteins .
Transcriptional Regulation: The expression of AHSG is regulated by various factors, including testosterone via androgen receptor activation . The AHSG gene harbors putative androgen receptor response elements in its promoter sequence .
Post-Translational Modifications: AHSG undergoes complex proteolytic processing and circulates in blood and extracellular fluids as a partially phosphorylated glycoprotein .
Biomedical Research: AHSG is used in research to study its role in bone mineralization, inflammation, and metabolic processes .
Diagnostic Tools: AHSG levels are measured as biomarkers for various conditions, including cardiovascular diseases and metabolic disorders .
Therapeutic Strategies: AHSG has potential therapeutic applications in neuroprotection and the treatment of neurological diseases .
Development: AHSG is more abundant in fetal blood and plays a crucial role in brain development and bone tissue formation during early development .
Aging and Disease: AHSG levels and activity are associated with various age-related conditions, including cardiovascular diseases and metabolic disorders . It also contributes to the prevention of soft tissue calcification and modulates inflammation .
