Recombinant Proteins
Product List
GIMAP5 Human
GTPase, IMAP Family Member 5 Human Recombinant
GIMAP5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
GIMAP6 Human
GTPase, IMAP Family Member 6 Human Recombinant
Introduction
The GTPase IMAP (Immunity-Associated Nucleotide-binding Protein) family is a group of proteins belonging to the GTP-binding superfamily. These proteins are characterized by their ability to bind and hydrolyze GTP, a critical function in various cellular processes. The IMAP family is also known as the GIMAP (GTPase of the Immunity-Associated Protein) family. Members of this family include GIMAP1, GIMAP2, GIMAP4, GIMAP5, GIMAP6, GIMAP7, and GIMAP8 .
Key Biological Properties: GIMAP proteins are involved in the regulation of immune cell survival and apoptosis. They possess GTPase activity, which is essential for their function .
Expression Patterns and Tissue Distribution: GIMAP genes are predominantly expressed in immune cells, including T and B lymphocytes. They are clustered on chromosome 7 in humans and are highly conserved across vertebrates .
Primary Biological Functions: GIMAP proteins play a crucial role in the development and maintenance of the immune system. They are involved in the differentiation of T helper cells and the survival of mature B and T lymphocytes .
Role in Immune Responses and Pathogen Recognition: GIMAP proteins are essential for the proper functioning of the immune system. They help in the recognition of pathogens and the regulation of immune responses, contributing to the body’s defense mechanisms .
Mechanisms with Other Molecules and Cells: GIMAP proteins interact with each other and with other cellular components to regulate immune cell functions. They are involved in the movement of cellular cargo along the cytoskeletal network .
Binding Partners and Downstream Signaling Cascades: GIMAP proteins form dimers and interact with various binding partners to exert their functions. They are involved in downstream signaling cascades that regulate immune cell survival and apoptosis .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of GIMAP proteins are regulated at multiple levels, including transcriptional and post-translational modifications. Dysregulation of GIMAP family members has been observed in various cancers, indicating their role in disease pathogenesis .
Transcriptional Regulation and Post-Translational Modifications: GIMAP genes are regulated by transcription factors and undergo post-translational modifications such as phosphorylation, which modulate their activity and stability .
Biomedical Research: GIMAP proteins are studied for their role in immune cell regulation and their potential as therapeutic targets in immune-related diseases .
Diagnostic Tools and Therapeutic Strategies: The expression levels of GIMAP proteins can serve as biomarkers for certain cancers and immune disorders. Therapeutic strategies targeting GIMAP proteins are being explored for their potential to modulate immune responses .
Role Throughout the Life Cycle: GIMAP proteins are involved in various stages of the life cycle, from development to aging. They play a critical role in the development of the immune system and the maintenance of immune cell populations throughout life .
From Development to Aging and Disease: Dysregulation of GIMAP proteins has been linked to age-related immune dysfunction and various diseases, including cancer and autoimmune disorders .
