GIMAP6 Human

GTPase, IMAP Family Member 6 (GIMAP6) is a protein encoded by the GIMAP6 gene, which belongs to the GTPases of immunity-associated proteins (GIMAP) family. This family of proteins is characterized by the presence of GTP-binding and coiled-coil motifs, and they play crucial roles in the regulation of cell survival and immune functions .

The GIMAP6 gene is located on the long arm of chromosome 7, within a cluster of seven additional GIMAP genes . The protein encoded by this gene is involved in various cellular processes, including the regulation of lymphocyte survival and homeostasis . GIMAP proteins are conserved across vertebrates and are predominantly expressed in the cells of the hematopoietic system .

GIMAP6, like other members of the GIMAP family, is implicated in the development and maintenance of lymphocytes. These proteins are essential for the long-term survival of T lymphocytes in a quiescent state, which is crucial for maintaining their numbers in secondary lymphoid organs and peripheral circulation . Decreased expression of GIMAP6 has been associated with non-small cell lung cancer, highlighting its potential role in tumor suppression .

The GIMAP family of proteins has been identified in various organisms, including angiosperms, corals, nematodes, and snails, where they are implicated in protection from infections . The observed homology between GIMAP proteins and the plant avrRpt2 induced gene 1 (AIG1) suggests that these proteins may have evolved through convergent evolution .

Recent studies have suggested that GIMAP proteins may interact with each other and be involved in the movement of cellular cargo along the cytoskeletal network . Understanding the structure and functions of GIMAP6 and other GIMAP proteins can provide insights into their roles in immune regulation and potential therapeutic targets for diseases such as cancer.