Recombinant Proteins
Product List
ETS2 Human
V-Ets Avian Erythroblastosis Virus E26 Oncogene 2 Human Recombinant
ETS2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Protein C-Ets, also known as ETS1, is a transcription factor encoded by the ETS1 gene in humans. It belongs to the ETS (E26 transformation-specific) family of transcription factors, which is characterized by a conserved DNA-binding domain known as the ETS domain . The ETS family comprises 28 genes in humans and 27 in mice .
Key Biological Properties: ETS1 is a transcription factor that binds to specific DNA sequences to regulate gene expression. It is involved in various cellular processes, including differentiation, proliferation, and apoptosis .
Expression Patterns: ETS1 is expressed in multiple tissues, with high levels observed in immune tissues such as the thymus, spleen, and lymph nodes . It is also expressed in endothelial cells, vascular smooth muscle cells, and epithelial cancer cells .
Tissue Distribution: ETS1 is predominantly found in immune cells, including B cells, T cells, NK cells, and non-lymphoid immune cells . It is also present in other tissues such as the liver, kidney, lung, brain, and male reproductive tissue .
Primary Biological Functions: ETS1 plays a crucial role in regulating immune cell function, cellular differentiation, and tumor progression . It is involved in the regulation of genes associated with cell cycle control, cell migration, and angiogenesis .
Role in Immune Responses and Pathogen Recognition: ETS1 is essential for the development and function of natural killer (NK) cells, which are critical for immune defense against tumors and pathogens . It regulates the expression of key transcription factors that control NK cell differentiation and activation .
Mechanisms with Other Molecules and Cells: ETS1 interacts with various co-regulatory partners to elicit gene-specific responses . It binds to DNA sequences containing a GGAA/T core element and can be activated by phosphorylation and interactions with other transcription factors .
Binding Partners and Downstream Signaling Cascades: ETS1 can form homodimers or heterodimers with other ETS family members, enhancing its DNA-binding affinity and specificity . It is also involved in downstream signaling cascades, such as the MAPK pathway, which phosphorylates and activates ETS1 .
Transcriptional Regulation: ETS1 expression is regulated by various signaling pathways, including the EGFR signaling pathway . Sequential activation of ETS proteins provides a sustained transcriptional response to extracellular signals .
Post-Translational Modifications: ETS1 activity is modulated by post-translational modifications, such as phosphorylation. Phosphorylation by MAPK and other kinases can either activate or inhibit ETS1’s DNA-binding ability .
Biomedical Research: ETS1 is widely studied in the context of cancer biology, immune regulation, and developmental biology . It serves as a model for understanding transcription factor networks and gene regulation .
Diagnostic Tools: Antibodies targeting ETS1 are used in various scientific applications, including Western Blot, Immunohistochemistry, and ELISA . These tools help in detecting ETS1 expression in different tissues and disease states.
Therapeutic Strategies: ETS1 is a potential therapeutic target for cancer treatment, as its dysregulation is associated with tumor progression and metastasis . Inhibitors targeting ETS1 activity are being explored as potential cancer therapies .
Development: ETS1 is involved in the differentiation and development of various cell types, including immune cells and endothelial cells . It plays a critical role in embryonic development and tissue morphogenesis .
Aging and Disease: Dysregulation of ETS1 is linked to various diseases, including cancer, autoimmune disorders, and inflammatory diseases . Its role in immune cell function makes it a key player in age-related immune decline and chronic inflammation .
