Recombinant Proteins
Product List
SNX1 Human
Sorting Nexin 1 Human Recombinant
SNX3 Human
Sorting Nexin 3 Human Recombinant
SNX3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (1-162 a.a) and having a molecular mass of 20.9kDa.
SNX3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SNX5 Human
Sorting Nexin 5 Human Recombinant
SNX5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Sorting nexins (SNXs) are a diverse family of proteins characterized by the presence of a phospholipid-binding motif known as the PX domain . These proteins are primarily involved in intracellular trafficking and protein sorting. SNXs can be classified based on their domain composition and functional roles. For instance, some SNXs possess additional domains such as the BAR domain, which is involved in membrane curvature and tubulation .
Key Biological Properties: SNXs are cytoplasmic and membrane-associated proteins that play crucial roles in endocytosis and protein trafficking . They are known for their ability to bind specific phospholipids and form protein-protein complexes .
Expression Patterns and Tissue Distribution: SNXs are ubiquitously expressed across various tissues, with specific expression patterns depending on the type of SNX. For example, SNX4 is prominently expressed in the brain and has been implicated in neurodegenerative diseases .
Primary Biological Functions: SNXs are essential for the regulation of endocytic pathways, which include the internalization of extracellular components and their sorting within the cell . They are involved in the recycling of receptors to the cell surface, degradation in lysosomes, and transport to the trans-Golgi network .
Role in Immune Responses and Pathogen Recognition: SNXs play a role in immune responses by regulating the trafficking of immune receptors and other signaling molecules. They are also involved in the recognition and processing of pathogens, contributing to the immune defense mechanisms .
Mechanisms with Other Molecules and Cells: SNXs interact with various molecules and cellular components through their PX domain and other protein-protein interaction motifs . These interactions facilitate their localization to specific cellular membranes and the formation of functional complexes .
Binding Partners and Downstream Signaling Cascades: SNXs bind to phosphoinositides and other membrane-associated proteins, which helps in the recruitment of additional signaling molecules. This leads to the activation of downstream signaling cascades that regulate various cellular processes .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of SNXs are regulated at multiple levels, including transcriptional and post-translational modifications . Transcriptional regulation involves the control of SNX gene expression by various transcription factors, while post-translational modifications such as phosphorylation and ubiquitination modulate their activity and stability .
Biomedical Research: SNXs are valuable tools in biomedical research for studying intracellular trafficking and protein sorting mechanisms . They are also used to investigate the pathogenesis of various diseases, including neurodegenerative disorders and cardiovascular diseases .
Diagnostic Tools and Therapeutic Strategies: SNXs have potential applications in the development of diagnostic tools and therapeutic strategies. For instance, targeting SNX pathways could provide novel therapeutic approaches for diseases associated with dysfunctional protein trafficking .
Role Throughout the Life Cycle: SNXs play critical roles throughout the life cycle, from development to aging and disease . They are involved in maintaining cellular homeostasis, regulating cell cycle progression, and responding to stress . Dysregulation of SNX functions can lead to various pathological conditions, highlighting their importance in health and disease .
