SNX3 Human

SNX3 is one of the simplest structured isoforms in the sorting nexin family. It contains a PX domain that facilitates its binding to phosphatidylinositol-3-phosphate (PI3P) enriched endosomal membranes . This binding is essential for its role in endosomal sorting and trafficking.

SNX3 is involved in the retromer complex, a multi-protein assembly that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network or the plasma membrane . The retromer complex is crucial for maintaining cellular homeostasis and proper functioning of various signaling pathways.

Recent studies have highlighted the importance of SNX3 in the pathogenesis of several diseases, particularly cardiovascular diseases. Increased levels of SNX3 have been observed in failing hearts from human patients and animal models . SNX3 promotes the retromer-dependent nuclear trafficking of STAT3, a transcription factor involved in various cellular processes, including inflammation and apoptosis . Dysregulation of this pathway can lead to myocardial injury and heart failure.

Recombinant human SNX3 is a form of SNX3 that is produced through recombinant DNA technology. This involves inserting the gene encoding SNX3 into an expression system, such as bacteria or yeast, to produce the protein in large quantities. Recombinant proteins are widely used in research and therapeutic applications due to their high purity and consistency .

Recombinant human SNX3 is used in various research applications to study its role in cellular processes and disease mechanisms. It is also used in drug discovery and development to identify potential therapeutic targets for diseases associated with SNX3 dysregulation .