Recombinant Proteins
Product List
MAP1LC3A Human
Microtubule-Associated Protein 1 Light Chain 3 Alpha Human Recombinant
MAP1LC3B Human
Microtubule-Associated Protein 1 Light Chain 3 Beta Human Recombinant
MAP1LC3B is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MAP1LC3B2 Human
Microtubule-Associated Protein 1 Light Chain 3 Beta 2 Human Recombinant
MAP1LC3B2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MAPRE1 Human
Microtubule-Associated Protein, RP/EB Family, Member 1 Human Recombinant
MAPRE2 Human
Microtubule-Associated Protein, RP/EB Family, Member 2 Human Recombinant
MAPRE2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MAPRE3 Human
Microtubule-Associated Protein, RP/EB Family, Member 3 Human Recombinant
MAPRE3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MAPT Human
Microtubule-Associated Protein Tau Human Recombinant
MAPT Recombinant Human (Isoform-4) produced in E.Coli is a single, non-glycosylated polypeptide chain containing 372 amino acids (1-352 a.a.) and having a molecular mass of 38.9 kDa (Real molecular weight on SDS-PAGE will be shift up). The MAPT is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
MAPT Human 381a.a.
Microtubule-Associated Protein Tau 381 a.a. Human Recombinant
The MAPT is purified by proprietary chromatographic techniques.
MAPT Human 383a.a.
Microtubule-Associated Protein Tau 383 a.a. Human Recombinant
MAPT Human Recombinant (Isoform 3) fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 403 amino acids (1-383 a.a.) and having a molecular mass of 42.1kDa (Molecular size on SDS-PAGE will appear higher). The MAPT is purified by proprietary chromatographic techniques.
MAPT Human 412a.a.
Microtubule-Associated Protein Tau 412 a.a. Human Recombinant
MAPT Human Recombinant (Isoform 5) fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 432 amino acids (1-412 a.a.) and having a molecular mass of 45.1kDa (Molecular size on SDS-PAGE will appear higher). The MAPT is purified by proprietary chromatographic techniques.
Introduction
Microtubule-Associated Proteins (MAPs) are proteins that interact with microtubules, which are part of the cellular cytoskeleton. They play a crucial role in stabilizing microtubules and facilitating the transport of cellular components . MAPs are classified into several categories based on their structure and function:
MAPs exhibit diverse biological properties:
- Key Biological Properties: MAPs stabilize microtubules by binding to tubulin dimers, which can occur with either polymerized or depolymerized tubulin .
- Expression Patterns: Different MAPs are expressed in various cell types. For example, MAP1 is found in the axons and dendrites of nerve cells .
- Tissue Distribution: MAPs are distributed across different tissues, with specific MAPs like MAP2 being involved in neuronal development and present in mature dendrites .
MAPs have several primary biological functions:
- Microtubule Stabilization: They stabilize microtubules, which is essential for maintaining cell structure and facilitating intracellular transport .
- Role in Immune Responses and Pathogen Recognition: MAPs are involved in immune responses by regulating the stability and dynamics of microtubules, which are crucial for cell division and motility .
MAPs interact with other molecules and cells through various mechanisms:
The expression and activity of MAPs are tightly regulated:
MAPs have several applications in biomedical research and therapeutic strategies:
- Biomedical Research: MAPs are studied to understand their role in neurodegenerative diseases like Alzheimer’s disease .
- Diagnostic Tools: MAPs, particularly Tau protein, are used as biomarkers for diagnosing neurodegenerative diseases .
- Therapeutic Strategies: Targeting MAPs is being explored as a potential therapeutic approach for treating diseases like cancer and neurodegenerative disorders .
MAPs play a role throughout the life cycle, from development to aging and disease:
