MAP1LC3B2 Human
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Description
MAP1LC3B2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The MAP1LC3B2 gene is located on chromosome 16 in humans . The protein encoded by this gene is a subunit of the larger MAP1A and MAP1B proteins, which are involved in microtubule assembly and are important for neurogenesis . LC3B2 is a ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes), playing a significant role in the autophagy pathway .
LC3B2 is central to the autophagy pathway, where it functions in autophagy substrate selection and autophagosome biogenesis . Autophagy is a cellular process that involves the bulk degradation of cytoplasmic components, including damaged organelles and misfolded proteins, to maintain cellular homeostasis . LC3B2 is the most widely used marker of autophagosomes, the double-membrane vesicles that sequester cytoplasmic material for degradation .
Mutations or dysregulation of the MAP1LC3B2 gene have been associated with various diseases, including adenocarcinoma and adrenal gland ganglioneuroblastoma . The protein’s role in autophagy also implicates it in neurodegenerative diseases, where impaired autophagy can lead to the accumulation of toxic protein aggregates .
