Recombinant Proteins
Product List
GABARAP Human
GABA(A) Receptor-Associated Protein Human Recombinant
GABARAPL1 Human
GABA(A) Receptor-Associated Protein Like 1 Human Recombinant
GABARAPL2 Human
GABA(A) Receptor-Associated Protein Like 2 Human Recombinant
GABARAPL2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Gamma-aminobutyric acid A receptor-associated protein (GABARAP) is a protein encoded by the GABARAP gene in humans. It shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B . GABARAP is involved in clustering neurotransmitter receptors by mediating interaction with the cytoskeleton .
Key Biological Properties: GABARAP is highly positively charged in its N-terminus . It is a member of the microtubule-associated protein family and plays a role in intracellular receptor transport and autophagy pathways .
Expression Patterns and Tissue Distribution: GABARAP is expressed in various tissues, including the central nervous system, where it clusters neurotransmitter receptors . It is also involved in selective autophagy processes, including mitochondrial autophagy, endoplasmic reticulum autophagy, and Golgi autophagy .
Primary Biological Functions: GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton . It is involved in intracellular receptor transport and autophagy pathways .
Role in Immune Responses and Pathogen Recognition: GABARAP plays a role in the immune response by participating in selective autophagy processes, which are crucial for pathogen recognition and elimination .
Mechanisms with Other Molecules and Cells: GABARAP interacts with the cytoskeleton to cluster neurotransmitter receptors . It also interacts with various proteins involved in autophagy pathways .
Binding Partners and Downstream Signaling Cascades: GABARAP binds to microtubule-associated proteins and other autophagy-related proteins to facilitate intracellular receptor transport and autophagy .
Regulatory Mechanisms Controlling Expression and Activity: GABARAP expression and activity are regulated by transcriptional and post-translational modifications . Protein transport, local protein synthesis, and synaptic protein degradation shape the transmission efficiency of excitatory synapses .
Transcriptional Regulation and Post-Translational Modifications: Calcium entering through L-type voltage-gated calcium channels can regulate GABARAP function by means of changes in transcription, phosphorylation, trafficking, and lateral diffusion of receptors on the plasma membrane .
Biomedical Research: GABARAP is a target for studying intracellular receptor transport and autophagy pathways .
Diagnostic Tools: Fluorescent peptides designed from GABARAP binders enable live neuronal staining and visualization of gephyrin in the postsynaptic sites with submicron resolution .
Therapeutic Strategies: Targeting GABARAP and its associated proteins can modulate GABAergic signaling, providing potential therapeutic strategies for neurodevelopmental disorders, neurodegenerative diseases, and mental illnesses .
Role Throughout the Life Cycle: GABARAP is involved in various life processes, including intracellular receptor transport and autophagy pathways . It plays a crucial role in the regulation of many life processes, such as lowering blood pressure, treating anxiety and arrhythmia, controlling hormone secretion, and enhancing liver and kidney functions .
GABARAP’s involvement in these processes highlights its importance from development to aging and disease .
