GABARAPL1 Human

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). It plays a crucial role in regulating neuronal excitability throughout the nervous system. GABA exerts its effects through two main types of receptors: GABA(A) and GABA(B). Among these, GABA(A) receptors are ligand-gated chloride channels that mediate fast synaptic inhibition.

GABA(A) Receptor-Associated Protein Like 1 (GABARAPL1) is a protein encoded by the GABARAPL1 gene in humans. It belongs to the MAP1 LC3 family and is involved in various cellular processes, including autophagy and intracellular trafficking .

GABARAPL1 is a ubiquitin-like modifier that plays a significant role in the formation of autophagosomal vacuoles. It is involved in the elongation of the phagophore membrane and is essential for the maturation of autophagosomes . Additionally, GABARAPL1 increases the cell surface expression of kappa-type opioid receptors by facilitating their anterograde intracellular trafficking .

GABARAPL1 is implicated in several physiological processes, including the cellular response to nutrient starvation and the remodeling of subdomains of the endoplasmic reticulum into autophagosomes . Dysregulation of GABARAPL1 has been associated with various diseases, such as Joubert Syndrome 20 and sarcoma .

Recombinant GABARAPL1 is used in research to study its role in autophagy and intracellular trafficking. It is also utilized to understand its interactions with other proteins and its involvement in various cellular processes. The study of GABARAPL1 can provide insights into the mechanisms underlying neuropsychiatric disorders and other diseases associated with autophagy dysfunction .