GABARAPL2 Human

GABA(A) Receptor-Associated Protein Like 2 (GABARAPL2) is a protein encoded by the GABARAPL2 gene in humans. This protein is part of the GABA(A) receptor-associated protein family, which plays a crucial role in the central nervous system (CNS) by modulating inhibitory neurotransmission. GABARAPL2 is also known by several aliases, including GATE-16, GEF2, and ATG8C .

GABARAPL2 is a ubiquitin-like modifier involved in various cellular processes, including intra-Golgi traffic and autophagy. It modulates intra-Golgi transport by coupling NSF (N-ethylmaleimide-sensitive factor) activity with SNARE (Soluble NSF Attachment Protein Receptor) activation. This protein stimulates the ATPase activity of NSF, which in turn promotes the association with GOSR1 (Golgi SNAP Receptor Complex Member 1) .

In the context of autophagy, GABARAPL2 plays a role in the maturation of autophagosomes, which are essential for the degradation and recycling of cellular components. It is particularly important in mitophagy, a selective form of autophagy that targets damaged or excess mitochondria for degradation, thereby maintaining mitochondrial quality and quantity .

GABARAPL2 is involved in several physiological pathways, including vesicle-mediated transport and selective autophagy. Its role in autophagy is critical for cellular homeostasis and the prevention of various diseases. Dysregulation of GABARAPL2 has been associated with several disorders, including Joubert Syndrome 20 and Amyotrophic Lateral Sclerosis Type 22 .

Recombinant GABARAPL2 is a human-made version of the protein, produced using recombinant DNA technology. This allows for the study of its structure, function, and interactions in a controlled laboratory setting. Recombinant proteins are invaluable tools in biomedical research, enabling scientists to investigate the molecular mechanisms underlying various physiological and pathological processes.