Recombinant Proteins
Product List
SYT1 Human
Synaptotagmin I Human Recombinant
SYT1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
SYT11 Human
Synaptotagmin XI Human Recombinant
SYT13 Human
Synaptotagmin XIII Human Recombinant
SYT13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SYT3 Human
Synaptotagmin III Human Recombinant
SYT3 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SYT4 Human
Synaptotagmin IV Human Recombinant
SYT5 Human
Synaptotagmin V Human Recombinant
Introduction
Synaptotagmins (SYTs) are a family of membrane-trafficking proteins characterized by an N-terminal transmembrane region, a variable linker, and two C-terminal C2 domains (C2A and C2B) . There are 17 isoforms in the mammalian synaptotagmin family . These proteins play a crucial role in the regulation of neurotransmitter release and hormone secretion .
Key Biological Properties: Synaptotagmins are known for their role as calcium sensors in the regulation of neurotransmitter release . They have a high degree of homology in the C2 domains, although not all synaptotagmins bind to calcium .
Expression Patterns and Tissue Distribution: Synaptotagmins are widely distributed in the brain and endocrine tissues . For example, synaptotagmin-1 is localized to synaptic vesicles in the pre-synaptic axon terminal .
Primary Biological Functions: Synaptotagmins function as calcium sensors that regulate neurotransmitter release and hormone secretion . They are involved in early synaptic vesicle docking to the presynaptic membrane and late steps of calcium-evoked synaptic vesicle fusion .
Role in Immune Responses and Pathogen Recognition: While synaptotagmins are primarily known for their role in neurotransmission, they may also play a role in immune responses and pathogen recognition, although this area requires further research.
Mechanisms with Other Molecules and Cells: Synaptotagmins interact with various molecules such as β-neurexin and SNAP-25 . Calcium-binding alters the protein-protein interactions of synaptotagmin, increasing its affinity for syntaxin .
Binding Partners and Downstream Signaling Cascades: Synaptotagmins bind to phosphatidylinositol bisphosphate (PIP2) in the presence of calcium ions, suggesting a role in lipid signaling .
Biomedical Research: Synaptotagmins are extensively studied in the context of neurotransmission and synaptic vesicle exocytosis .
Diagnostic Tools and Therapeutic Strategies: Synaptotagmins have potential applications in developing diagnostic tools and therapeutic strategies for neurological disorders .
