Recombinant Proteins
Product List
KCTD11 Human
Potassium Channel Tetramerisation Domain Containing 11 Human Recombinant
KCTD15 Human
Potassium Channel Tetramerisation Domain Containing 15 Human Recombinant
KCTD15 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
KCTD4 Human
Potassium Channel Tetramerisation Domain Containing 4 Human Recombinant
KCTD5 Human
Potassium Channel Tetramerisation Domain Containing 5 Human Recombinant
Introduction
The KCTD (Potassium Channel Tetramerization Domain) family of proteins consists of 25 members . These proteins share a conserved N-terminal domain known as the BTB (Broad complex, Tramtrack, and Bric-a-brac) domain, which is essential for protein oligomerization and protein-protein interactions . KCTD proteins can be classified into seven clades based on their sequence homology and biological functions .
Key Biological Properties: KCTD proteins are involved in various biological processes, including protein degradation, transcriptional repression, and cytoskeleton regulation . They have relatively conserved N-terminal domains and variable C-termini .
Expression Patterns and Tissue Distribution: KCTD proteins are expressed in various tissues, with some members showing tissue-specific expression patterns . For example, KCTD12 and KCTD13 are predominantly expressed in the brain and play roles in neurodevelopment .
Primary Biological Functions: KCTD proteins are involved in proliferation, differentiation, apoptosis, and metabolism . They play crucial roles in immune responses and pathogen recognition by regulating signaling pathways and interacting with other proteins .
Role in Immune Responses and Pathogen Recognition: KCTD proteins modulate immune responses by interacting with key signaling molecules and pathways, such as the cAMP signaling pathway .
Mechanisms with Other Molecules and Cells: KCTD proteins act as adapters, recruiting substrates for ubiquitination and degradation . They interact with E3-ubiquitin ligases through their BTB domain .
Binding Partners and Downstream Signaling Cascades: KCTD proteins bind to various partners, including cullin E3 ubiquitin ligase complexes, and modulate downstream signaling cascades . For example, KCTD5 regulates cAMP signaling by modulating the influx of Zn2+ via the Zip14 transporter .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of KCTD proteins are regulated at multiple levels, including transcriptional regulation and post-translational modifications .
Transcriptional Regulation: KCTD genes are regulated by various transcription factors and signaling pathways .
Post-Translational Modifications: KCTD proteins undergo post-translational modifications, such as ubiquitination, which modulate their stability and activity .
Biomedical Research: KCTD proteins are studied for their roles in various diseases, including cancer, neurological disorders, and obesity .
Diagnostic Tools: KCTD proteins, such as KCTD5, are being investigated as potential biomarkers for cancer diagnosis and prognosis .
Therapeutic Strategies: Targeting KCTD proteins and their interactions with other molecules is being explored as a therapeutic strategy for various diseases .
Role Throughout the Life Cycle: KCTD proteins play essential roles throughout the life cycle, from development to aging and disease . They are involved in neurodevelopment, immune responses, and cell cycle regulation .
Development to Aging and Disease: KCTD proteins are crucial for proper development and function of various tissues and organs. Dysregulation of KCTD proteins has been associated with diseases such as cancer, neurological disorders, and metabolic diseases .
