KCTD15 Human
Description
KCTD15 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Potassium Channel Tetramerisation Domain Containing 15 (KCTD15) is a protein encoded by the KCTD15 gene in humans. This protein is part of the potassium channel tetramerization domain-containing protein family, which plays a crucial role in the formation and function of potassium channels. These channels are essential for maintaining the electrical excitability of cells, particularly in the nervous system and heart.
KCTD15 contains a specific domain known as the tetramerization domain, which is crucial for the assembly of potassium channels into functional tetrameric structures. This domain is similar to the T1 domain found in voltage-gated potassium channels. The tetramerization domain ensures that the potassium channels are correctly assembled and function properly.
Potassium channels are involved in various physiological processes, including the generation of action potentials, neuronal excitability, and plasticity. They are divided into two main groups based on their inactivation properties: the nearly non-inactivating ‘delayed’ group and the fast inactivating ‘transient’ group .
The gating mechanism of potassium channels is voltage-dependent, meaning that the channels open or close in response to changes in the membrane potential. This mechanism is crucial for the proper functioning of neurons and muscle cells. Additionally, potassium channels can be regulated by various signals, including changes in intracellular calcium concentration, binding of transmitters, and activation by intracellular kinases and GTP-binding proteins .
KCTD15 has been implicated in several physiological and pathological processes. During embryonic development, KCTD15 interferes with neural crest formation and inhibits AP2 transcriptional activity by interacting with its activation domain . Mutations or dysregulation of KCTD15 have been associated with conditions such as brachydactyly, type D, and coronary artery anomalies .
Recombinant proteins, including human recombinant KCTD15, are produced using recombinant DNA technology. This involves inserting the gene encoding KCTD15 into a suitable expression system, such as bacteria or mammalian cells, to produce the protein in large quantities. Human recombinant KCTD15 is used in various research applications to study its structure, function, and role in disease.
