KCTD15 Antibody
Potassium channel tetramerisation domain containing 15, Mouse Anti Human
Cat. No.
BT21618
Source
Synonyms
BTB/POZ domain-containing protein KCTD15, Potassium channel tetramerisation domain containing 15, KCTD15, MGC2628, MGC25497.
Appearance
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Product Specs
Introduction
KCTD15 protein is encoded in humans by the KCTD15 gene. It is highly expressed in the brain, particularly the hypothalamus. Research has identified the KCTD15 potassium channel as a genetic locus associated with a higher body mass index (BMI) in humans. This association is observed alongside other genes like GNPDA2, MTCH2, FTO, and TMEM18. Studies examining single nucleotide polymorphisms (SNPs) in individuals with and without diabetes revealed a strong link between FTO and obesity. Notably, MTCH2 and GNPDA2 were also significantly associated with elevated BMI levels.
Formulation
The antibody is supplied at a concentration of 1mg/ml in a solution of phosphate-buffered saline (PBS) at pH 7.4 with 0.1% sodium azide as a preservative.
Storage Procedures
For short-term storage (up to 1 month), keep at 4°C. For extended storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Stability / Shelf Life
The antibody has a shelf life of 12 months when stored at -20°C and 1 month when stored at 4°C.
Applications
The KCTD15 antibody has undergone rigorous testing using ELISA, Western blot, and Immunofluorescence analysis to ensure its specificity and reactivity. However, optimal working dilutions should be determined empirically for each application. For Western blot and Immunofluorescence, a dilution range of 1:250 to 1:500 is recommended, with a starting dilution of 1:250.
Synonyms
BTB/POZ domain-containing protein KCTD15, Potassium channel tetramerisation domain containing 15, KCTD15, MGC2628, MGC25497.
Purification Method
KCTD15 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT4C3AT.
Immunogen
Anti-human KCTD15 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human KCTD15 amino acids 1-234 purified from E. coli.
Ig Subclass
Mouse IgG3 heavy chain and L light chain.
Product Science Overview
Gene and Protein Information
Function and Expression
KCTD15 is involved in several critical functions:
Clinical Significance
Mouse Anti Human KCTD15 Antibody
The Mouse Anti Human KCTD15 antibody is a monoclonal antibody used in research to study the KCTD15 protein. Here are some key details:
- Type: Mouse Anti Human Monoclonal .
- Immunogen: Derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human KCTD15 amino acids 1-234 purified from E. coli .
- Applications: This antibody has been tested by ELISA, Western blot, and Immunofluorescence analysis to ensure specificity and reactivity .
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