Recombinant Proteins
Product List
BATF Human
Basic Leucine Zipper Transcription Factor Human Recombinant
BATF Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 145 amino acids (1-125 a.a.) and having a molecular mass of 16.2kDa. The BATF is purified by proprietary chromatographic techniques.
BATF3 Human
Basic Leucine Zipper Transcription Factor ATF-Like 3 Human Recombinant
BATF3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Key Biological Properties: BATF is crucial for the differentiation and function of various immune cells, including T-helper (Th) cells and B cells . It lacks a transactivation domain, which means it requires dimerization with other proteins to exert its effects .
Expression Patterns: BATF is predominantly expressed in immune cells, particularly in T and B lymphocytes . Its expression is regulated by developmental transitions and environmental cues .
Tissue Distribution: BATF is primarily found in lymphoid tissues, such as the spleen and lymph nodes, where it plays a critical role in immune responses .
Primary Biological Functions: BATF is essential for the differentiation of Th17 cells, follicular helper T (Tfh) cells, and regulatory T (Treg) cells . It regulates the expression of key transcription factors and cytokines involved in immune responses .
Role in Immune Responses: BATF is involved in the regulation of immune responses by controlling the differentiation and function of various T cell subsets . It plays a role in pathogen recognition and the development of effective immune responses .
Mechanisms with Other Molecules and Cells: BATF forms heterodimers with JUN proteins to bind to AP-1 sites on DNA and regulate gene transcription . It interacts with other transcription factors, such as IRF4, to modulate the expression of target genes .
Binding Partners: BATF primarily dimerizes with JUN proteins, but it can also interact with other bZIP proteins .
Downstream Signaling Cascades: BATF regulates the expression of genes involved in T cell differentiation and function, including those encoding cytokines and transcription factors .
Transcriptional Regulation: BATF expression is regulated by various transcription factors and signaling pathways, including those activated by T cell receptor (TCR) signaling .
Post-Translational Modifications: BATF activity can be modulated by post-translational modifications, such as phosphorylation, which affect its ability to bind DNA and interact with other proteins .
Biomedical Research: BATF is a valuable target in immunology research due to its role in T cell differentiation and function . It is studied in the context of autoimmune diseases, cancer, and infectious diseases .
Diagnostic Tools: Antibodies against BATF are used in various diagnostic applications, including Western blotting, immunohistochemistry, and flow cytometry .
Therapeutic Strategies: Modulating BATF activity has potential therapeutic applications in treating autoimmune diseases, cancer, and other conditions involving dysregulated immune responses .
Development: BATF is crucial for the development of functional T and B cells, which are essential for adaptive immunity .
Aging and Disease: Dysregulation of BATF expression or function can lead to immune-related diseases, such as autoimmune disorders and cancer . Understanding BATF’s role in these processes can inform the development of new therapeutic strategies .
