Recombinant Proteins
Product List
BIRC5 Human
Baculoviral IAP Repeat-Containing 5 Human Recombinant
BIRC7 Human
Baculoviral IAP Repeat-Containing 7 Human Recombinant
BIRC7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 318 amino acids (1-298 a.a.) and having a molecular mass of 34kDa. BIRC7 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
BIRC7 Human, (1-280 a.a.)
Baculoviral IAP Repeat-Containing 7 (1-280 a.a.) Human Recombinant
BIRC7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Baculoviral IAP Repeat-Containing (BIRC) proteins are a family of proteins characterized by the presence of one or more Baculoviral IAP Repeat (BIR) domains. These proteins are also known as Inhibitor of Apoptosis Proteins (IAPs) due to their ability to inhibit apoptotic cell death. BIRC proteins are classified into several types based on the number and arrangement of BIR domains and other functional motifs they contain.
Key Biological Properties: BIRC proteins are involved in regulating apoptosis, cell division, and immune responses. They are known for their anti-apoptotic properties, which they achieve by binding to and inhibiting caspases, the enzymes responsible for executing apoptosis.
Expression Patterns: The expression of BIRC proteins varies across different tissues and developmental stages. Some BIRC proteins are ubiquitously expressed, while others show tissue-specific expression patterns.
Tissue Distribution: BIRC proteins are found in various tissues, including the brain, heart, liver, and immune cells. Their distribution is often correlated with their roles in regulating cell survival and immune responses.
Primary Biological Functions: The primary function of BIRC proteins is to inhibit apoptosis, thereby promoting cell survival. They achieve this by directly binding to and inhibiting caspases. Additionally, BIRC proteins are involved in regulating cell division and immune responses.
Role in Immune Responses: BIRC proteins play a crucial role in immune responses by regulating the survival of immune cells. They help maintain the balance between cell survival and death, which is essential for proper immune function.
Pathogen Recognition: Some BIRC proteins are involved in recognizing and responding to pathogen infections. They can modulate the immune response to ensure an effective defense against pathogens.
Mechanisms with Other Molecules and Cells: BIRC proteins interact with various molecules and cells to exert their functions. They bind to caspases to inhibit their activity and prevent apoptosis. Additionally, BIRC proteins can interact with other signaling molecules to regulate cell division and immune responses.
Binding Partners: BIRC proteins have several binding partners, including caspases, ubiquitin ligases, and other regulatory proteins. These interactions are crucial for their anti-apoptotic and regulatory functions.
Downstream Signaling Cascades: BIRC proteins are involved in several downstream signaling cascades that regulate cell survival, division, and immune responses. They can activate or inhibit various signaling pathways to achieve their functions.
Regulatory Mechanisms that Control Expression and Activity: The expression and activity of BIRC proteins are tightly regulated at multiple levels. Transcriptional regulation, post-transcriptional modifications, and protein-protein interactions all play a role in controlling BIRC protein levels and activity.
Transcriptional Regulation: The transcription of BIRC genes is regulated by various transcription factors and signaling pathways. These regulatory mechanisms ensure that BIRC proteins are expressed at appropriate levels in response to cellular signals.
Post-Translational Modifications: BIRC proteins undergo several post-translational modifications, including phosphorylation, ubiquitination, and proteolytic cleavage. These modifications can alter their stability, activity, and interactions with other proteins.
Biomedical Research: BIRC proteins are extensively studied in biomedical research due to their roles in apoptosis and cell survival. They are used as models to understand the mechanisms of cell death and survival.
Diagnostic Tools: BIRC proteins can serve as biomarkers for various diseases, including cancer and neurodegenerative disorders. Their expression levels can provide insights into disease progression and prognosis.
Therapeutic Strategies: Targeting BIRC proteins is a potential therapeutic strategy for treating diseases characterized by dysregulated apoptosis, such as cancer. Inhibitors of BIRC proteins are being developed as potential anti-cancer agents.
Role Throughout the Life Cycle: BIRC proteins play essential roles throughout the life cycle, from development to aging and disease. During development, they regulate cell survival and differentiation. In adulthood, they maintain tissue homeostasis and immune function. Dysregulation of BIRC proteins is associated with various diseases, including cancer, neurodegenerative disorders, and immune dysfunction.
