Recombinant Proteins
Product List
RANBP1 Human
RAN Binding Protein 1 Human Recombinant
RANBP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RANBP3 Human
RAN Binding Protein 3 Human Recombinant
RANBP3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
RAN Binding Protein (RanBP) is a family of proteins that interact with the Ras-related nuclear protein (Ran), a small GTPase involved in nucleocytoplasmic transport. RanBPs are essential for the regulation of the Ran GTPase cycle, which is crucial for various cellular processes, including mitosis and nuclear transport. RanBPs are classified based on their specific interactions with Ran and their roles in different cellular functions .
Key Biological Properties: RanBPs are characterized by their ability to bind Ran in its GTP-bound state, facilitating the hydrolysis of GTP to GDP. This interaction is critical for the regulation of nucleocytoplasmic transport and other cellular processes .
Expression Patterns: RanBPs are ubiquitously expressed in various tissues, with higher expression levels observed in tissues with high rates of cell division, such as the thymus and bone marrow .
Tissue Distribution: RanBPs are found in both the nucleus and cytoplasm, reflecting their role in nucleocytoplasmic transport. They are also associated with the nuclear pore complex, where they facilitate the transport of proteins and RNA across the nuclear envelope .
Primary Biological Functions: RanBPs play a crucial role in the regulation of nucleocytoplasmic transport by interacting with Ran and other transport receptors. They are involved in the import and export of proteins and RNA, as well as the assembly of the mitotic spindle during cell division .
Role in Immune Responses: RanBPs have been implicated in the immune response by regulating the transport of immune-related proteins and RNA. They are also involved in the recognition and clearance of pathogens, as demonstrated in studies on invertebrates .
Pathogen Recognition: RanBPs contribute to the innate immune response by facilitating the transport of immune-related molecules that recognize and respond to pathogen invasion .
Mechanisms with Other Molecules and Cells: RanBPs interact with various molecules, including importins and exportins, to regulate the transport of cargo across the nuclear envelope. They also interact with other proteins involved in the Ran GTPase cycle, such as RanGAP and RCC1 .
Binding Partners: Key binding partners of RanBPs include Ran, importins, exportins, and other proteins involved in nucleocytoplasmic transport. These interactions are essential for the regulation of the Ran GTPase cycle and the transport of cargo molecules .
Downstream Signaling Cascades: RanBPs are involved in downstream signaling cascades that regulate various cellular processes, including cell cycle progression, DNA replication, and RNA processing .
Expression and Activity Regulation: The expression and activity of RanBPs are tightly regulated by various mechanisms, including transcriptional regulation and post-translational modifications. These regulatory mechanisms ensure the proper functioning of RanBPs in nucleocytoplasmic transport and other cellular processes .
Transcriptional Regulation: The transcription of RanBP genes is regulated by various transcription factors and signaling pathways that respond to cellular and environmental cues .
Post-Translational Modifications: RanBPs undergo post-translational modifications, such as phosphorylation and SUMOylation, which modulate their activity and interactions with other proteins .
Biomedical Research: RanBPs are widely studied in biomedical research due to their essential roles in nucleocytoplasmic transport and cell cycle regulation. They serve as model systems for understanding the mechanisms of protein transport and cell division .
Diagnostic Tools: RanBPs have potential applications as diagnostic markers for various diseases, including cancer. Abnormal expression or mutations in RanBP genes can serve as indicators of disease states .
Therapeutic Strategies: Targeting RanBPs and their interactions with Ran and other proteins offers potential therapeutic strategies for treating diseases such as cancer and viral infections. Inhibitors of RanBP interactions are being explored as potential drugs .
Development: RanBPs play a critical role in early development by regulating the transport of proteins and RNA necessary for cell division and differentiation .
Aging: The function of RanBPs may decline with age, leading to defects in nucleocytoplasmic transport and cellular homeostasis. This decline is associated with age-related diseases and cellular senescence .
Disease: Abnormalities in RanBP function are linked to various diseases, including cancer, neurodegenerative disorders, and viral infections. Understanding the role of RanBPs in these diseases can provide insights into their pathogenesis and potential therapeutic targets .
