Growth Factors
CD Antigens
Enzymes
Viral Antigens
Recombinant Proteins
Natural Proteins
Monoclonal Antibodies
Cytokines
Polyclonal Antibodies
Neurotrophins
Chemokines
Hormones
Recombinant Proteins
Product List
HDL Human
High Density Lipoprotein Human
Human High Density Lipoprotein (HDL) produced in Human plasma.
Shipped with Ice Packs 
LDL Human
Low-Density Lipoprotein Human
Human Low Density Lipoprotein (LDL) produced in Human plasma.
Shipped with Ice Packs
LDLRAP1 Human
Low Density Lipoprotein Receptor Adaptor Protein 1 Human Recombinant
LDLRAP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 328 amino acids (1-308) and having a molecular mass of 36.1kDa.
LDLRAP1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
LDLRAP1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
LRPAP1 Human
Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 Human Recombinant
LRPAP1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 348 amino acids (35-357) and having a molecular mass of 40.4kDa.
LRPAP1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
LRPAP1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
LRPAP1 Mouse
Low Density Lipoprotein Receptor Related Protein Associated Protein 1 Mouse Recombinant
LRPAP1 Mouse Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 355 amino acids (29-360 a.a) and
having a molecular mass of 41.4kDa. LRPAP1 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29661
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.
OLR1 Human
Oxidized Low Density Lipoprotein Receptor 1 Human Recombinant
OLR1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 216 amino acids (58-273) and having a molecular mass of 24.7 kDa.
The OLR1 is purified by proprietary chromatographic techniques.
The OLR1 is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
OLR1 Human, HEK
Oxidized Low Density Lipoprotein Receptor 1 Human Recombinant, HEK
OLR1 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Ser61-Gln273) containing a total of 221 amino acids, having a calculated molecular mass of 25.3kDa and fused to a 8 aa Flag tag at N-Terminus.
Shipped with Ice Packs
Cat. No.
BT29833
Source
HEK 293.
Appearance
Filtered White lyophilized (freeze-dried) powder.
OLR1 Human, Sf9
Oxidized Low Density Lipoprotein Receptor 1 Human Recombinant, Sf9
OLR1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 225 amino acids (58-273a.a) and having a molecular mass of 25.8kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).
OLR1 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29885
Source
Sf9,
Baculovirus cells.
Appearance
Sterile Filtered colorless solution.
Introduction
Definition and Classification
Density lipoproteins are complex particles composed of lipids and proteins that transport lipids through the bloodstream. They are classified based on their density and size into several types:
- Chylomicrons: The largest and least dense, primarily transport dietary triglycerides and cholesterol from the intestines to other tissues.
- Very Low-Density Lipoproteins (VLDL): Transport triglycerides from the liver to peripheral tissues.
- Intermediate-Density Lipoproteins (IDL): Formed from the degradation of VLDL, they are intermediate in size and density.
- Low-Density Lipoproteins (LDL): Known as “bad cholesterol,” they transport cholesterol to tissues but can lead to plaque formation in arteries.
- High-Density Lipoproteins (HDL): Known as “good cholesterol,” they transport cholesterol from tissues back to the liver for excretion.
Biological Properties
- Key Biological Properties: Density lipoproteins vary in lipid and protein composition, influencing their density and function. They contain apolipoproteins that serve as structural components and enzyme cofactors.
- Expression Patterns: The liver and intestines are primary sites for lipoprotein synthesis.
- Tissue Distribution: Lipoproteins circulate in the bloodstream, delivering lipids to various tissues, including adipose tissue, muscle, and the liver.
Biological Functions
- Primary Biological Functions: Transport of triglycerides, cholesterol, and fat-soluble vitamins.
- Role in Immune Responses: HDL has anti-inflammatory and antioxidant properties, playing a role in immune regulation.
- Pathogen Recognition: Certain lipoproteins can bind to and neutralize pathogens, contributing to innate immunity.
Modes of Action
- Mechanisms with Other Molecules and Cells: Lipoproteins interact with cell surface receptors, such as LDL receptors, to deliver lipids into cells.
- Binding Partners: Apolipoproteins on lipoproteins bind to specific receptors and enzymes.
- Downstream Signaling Cascades: Binding of lipoproteins to receptors can trigger intracellular signaling pathways that regulate lipid metabolism and cellular uptake.
Regulatory Mechanisms
- Expression and Activity: Regulated by dietary intake, hormonal signals, and genetic factors.
- Transcriptional Regulation: Genes encoding apolipoproteins and lipoprotein receptors are regulated by transcription factors like SREBP (Sterol Regulatory Element-Binding Protein).
- Post-Translational Modifications: Lipoproteins undergo modifications such as glycosylation and proteolysis, affecting their function and clearance.
Applications
- Biomedical Research: Studying lipoproteins helps understand cardiovascular diseases and metabolic disorders.
- Diagnostic Tools: Measuring levels of LDL and HDL cholesterol is crucial for assessing cardiovascular risk.
- Therapeutic Strategies: Targeting lipoprotein metabolism with drugs like statins and PCSK9 inhibitors to lower LDL cholesterol levels.
Role in the Life Cycle
- Development to Aging and Disease: Lipoprotein levels and composition change throughout life. Elevated LDL levels are associated with atherosclerosis and cardiovascular diseases, while HDL levels are protective. Age-related changes in lipoprotein metabolism can influence disease risk.
