LRPAP1 Mouse
Description
Product Specs
Product Science Overview
Low Density Lipoprotein Receptor Related Protein 1 (LRP1) is a multifunctional endocytic receptor that plays a crucial role in various biological processes. It is also known by several other names, including alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER), and cluster of differentiation 91 (CD91) . LRP1 is involved in receptor-mediated endocytosis and is highly expressed in multiple tissues, including neurons, hepatocytes, and vascular smooth muscle cells .
The LRP1 gene encodes a large precursor protein that is processed into two subunits: a 515 kDa alpha-chain and an 85 kDa beta-chain . The alpha-chain contains four ligand-binding domains, which interact with a variety of extracellular molecules, including growth factors, proteases, and extracellular matrix proteins . The beta-chain contains a cytoplasmic tail that is essential for the receptor’s role in endocytosis and signal transduction .
LRP1 is involved in numerous cellular processes, such as lipid metabolism, cell motility, and the regulation of vascular tone . It also plays a significant role in diseases like atherosclerosis, neurodegenerative diseases, and cancer .
In mice, LRP1 is a key regulator of oligodendrocyte progenitor cell (OPC) differentiation. It is highly expressed by OPCs and is rapidly downregulated as these cells differentiate into oligodendrocytes (OLs) . Studies have shown that the conditional deletion of LRP1 in adult mouse OPCs leads to an increase in the number of mature myelinating OLs, suggesting that LRP1 negatively regulates OPC differentiation . This has important implications for myelin repair in demyelinating diseases such as multiple sclerosis .
Recombinant LRP1 proteins are widely used in research to study their role in various biological processes and diseases. These recombinant proteins are typically produced in mammalian cell lines to ensure proper folding and post-translational modifications. Researchers use these proteins to investigate the signaling pathways and interactions mediated by LRP1, as well as its potential as a therapeutic target.
