LRPAP1 Antibody
Description
Product Specs
Product Science Overview
Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) is a multifunctional endocytic receptor that plays a crucial role in various biological processes, including lipid metabolism, cell signaling, and the regulation of inflammatory responses. LRP1 is also known by several other names, including alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER), and cluster of differentiation 91 (CD91) .
LRP1 is a large protein that is processed into two subunits: a 515 kDa alpha-chain and an 85 kDa beta-chain . The alpha-chain contains four ligand-binding domains that interact with a wide range of extracellular molecules, including lipoproteins, proteases, and growth factors . The beta-chain contains a cytoplasmic tail that is involved in signal transduction and endocytosis .
LRP1 is ubiquitously expressed in multiple tissues, with high abundance in vascular smooth muscle cells, hepatocytes, and neurons . It plays a key role in intracellular signaling and endocytosis, which implicates it in many cellular and biological processes, including lipid and lipoprotein metabolism, protease degradation, regulation of vascular tone, and cell migration .
LRP1 is involved in various diseases, including neurodegenerative diseases, atherosclerosis, and cancer . In the context of neurodegenerative diseases, LRP1 is a major receptor for apolipoprotein E (apoE) and amyloid-β (Aβ), which play critical roles in Alzheimer’s disease pathogenesis . LRP1 regulates inflammatory responses in peripheral tissues by modulating the release of inflammatory cytokines and phagocytosis .
In cardiovascular diseases, LRP1 has been shown to have a cardioprotective effect by reducing infarct size and cardiac dysfunction after acute myocardial infarction (AMI) . Activation of LRP1-mediated signaling in the heart with non-selective and selective LRP1 agonists has been linked with a powerful cardioprotective effect .
Mouse anti-human LRP1 antibodies are commonly used in research to study the function and regulation of LRP1 in various biological processes. These antibodies are designed to specifically bind to human LRP1, allowing researchers to investigate its role in different cellular contexts and disease models.
