OLR1 Human, Sf9

Oxidized Low Density Lipoprotein Receptor 1 (OLR1), also known as LOX-1, is a receptor protein that plays a crucial role in the recognition, internalization, and degradation of oxidized low-density lipoprotein (oxLDL). This receptor is part of the C-type lectin superfamily and is encoded by the OLR1 gene in humans .

The OLR1 gene is located on chromosome 12 (12p13.2) in humans . The gene is regulated through the cyclic AMP signaling pathway and produces multiple transcript variants through alternative splicing . The protein encoded by this gene is a type II membrane protein with a C-type lectin-like domain, which is essential for its binding to oxLDL .

OLR1 is primarily expressed on the surface of vascular endothelial cells, macrophages, and smooth muscle cells . Its primary function is to bind, internalize, and degrade oxLDL, which is a marker of atherosclerosis . The binding of oxLDL to LOX-1 induces vascular endothelial cell activation and dysfunction, leading to pro-inflammatory responses, oxidative stress, and apoptosis .

OLR1 has been implicated in various cardiovascular diseases, including atherosclerosis and myocardial infarction . The receptor’s interaction with oxLDL contributes to the formation of atherosclerotic plaques and endothelial cell injury . Additionally, mutations in the OLR1 gene have been associated with an increased risk of myocardial infarction and may modify the risk of Alzheimer’s disease .

The human recombinant OLR1 protein expressed in Sf9 cells is used for research purposes to study its structure, function, and role in disease. Sf9 cells, derived from the fall armyworm Spodoptera frugiperda, are commonly used in recombinant protein expression due to their high yield and post-translational modification capabilities.