MAPRE2 Human
Description
MAPRE2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The MAPRE2 gene is located on chromosome 18 and encodes a protein that shares significant homology with the adenomatous polyposis coli (APC) protein-binding EB1 gene family . The protein consists of several domains that facilitate its interaction with microtubules and other cellular components. Alternative splicing of the MAPRE2 gene results in multiple transcript variants, which may lead to the production of different protein isoforms .
MAPRE2 is essential for maintaining spindle symmetry during mitosis, a critical process for accurate chromosome segregation and cell division . It stabilizes microtubules by binding to their plus-ends, thereby promoting microtubule polymerization and anchoring them at centrosomes . This stabilization is vital for the proper formation and function of the mitotic spindle, ensuring that chromosomes are evenly distributed to daughter cells during cell division.
Additionally, MAPRE2 is involved in cell migration by regulating the dynamics of the microtubule cytoskeleton . It interacts with other proteins to facilitate the organization and elongation of microtubules, contributing to the polarized movement of cells .
MAPRE2 has been implicated in various diseases and conditions. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells . Abnormal expression or mutations in the MAPRE2 gene may disrupt microtubule dynamics, leading to defects in cell division and contributing to cancer development.
Moreover, diseases associated with MAPRE2 include congenital symmetric circumferential skin creases and multiple benign circumferential skin creases on limbs . These conditions are characterized by the presence of multiple skin folds, which may be linked to underlying defects in microtubule function and cell proliferation.
Human recombinant MAPRE2 is widely used in research to study its role in microtubule dynamics and cell division. By using recombinant proteins, scientists can investigate the specific functions and interactions of MAPRE2 in a controlled environment, providing insights into its mechanisms and potential therapeutic targets.
