FOLR1 Human, Sf9

FOLR1 is a glycosylated protein that can either attach to cell membranes through a glycosyl-phosphatidylinositol (GPI) linkage or exist in a soluble form. It is essential for embryonic development and normal cell proliferation . The recombinant form of FOLR1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 218 amino acids, with a molecular mass of approximately 25.6 kDa .

FOLR1 is expressed in various tissues, including the choroid plexus, kidneys, and lungs. It is particularly abundant in epithelial tissues and is involved in receptor-mediated endocytosis, a process crucial for cellular uptake of folate .

The recombinant form of FOLR1 (Human Recombinant, sf9) is used extensively in laboratory research. It is produced in Sf9 Baculovirus cells and purified using proprietary chromatographic techniques. This recombinant protein is valuable for studying folate metabolism, receptor-mediated endocytosis, and related cellular processes .

The FOLR1 protein solution is typically formulated in phosphate-buffered saline (PBS) with 10% glycerol. For short-term storage, it can be kept at 4°C, while for long-term storage, it is recommended to store the protein at -20°C with a carrier protein to prevent multiple freeze-thaw cycles .

FOLR1 is crucial for understanding folate metabolism and its role in various biological processes. Its high affinity for folic acid makes it a significant target for drug delivery systems, especially in cancer research, where folate receptors are often overexpressed in certain types of tumors .