MORF4L1 Human

Mortality Factor 4 Like 1 Human Recombinant
Cat. No.
BT14227
Source
Escherichia Coli.
Synonyms
Mortality factor 4-like protein 1, MORF-related gene 15 protein, Protein MSL3-1, Transcription factor-like protein MRG15, MORF4L1, MRG15, FWP006, HSPC008, HSPC061, PP368, Eaf3, MEAF3, S863-6, HsT17725, MORFRG15.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

MORF4L1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 347 amino acids (1-323 a.a) and having a molecular mass of 39.8kDa.
MORF4L1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Mortality factor 4-like protein 1 (MORF4L1), a member of the MRG family, is found in the NuA4 histone acetyltransferase (HAT) complex. This complex plays a crucial role in activating specific genes by primarily acetylating nucleosomal histones H4 and H2A. MORF4L1, a transcription factor present in various human tissues, has counterparts in numerous eukaryotes, collectively forming the MRG protein family. Its C-terminal region houses a conserved MRG domain, which interacts with the tumor suppressor protein retinoblastoma and a nucleoprotein.
Description
Recombinant Human MORF4L1, produced in E. coli, is a non-glycosylated polypeptide chain consisting of 347 amino acids (1-323 a.a) with a molecular weight of 39.8 kDa. It is fused to a 24 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
The MORF4L1 protein solution (1mg/ml) is supplied in a buffer containing 20mM Tris-HCl (pH 8.0), 30% glycerol, 0.15M NaCl, and 1mM DTT.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 85.0% as determined by SDS-PAGE analysis.
Synonyms
Mortality factor 4-like protein 1, MORF-related gene 15 protein, Protein MSL3-1, Transcription factor-like protein MRG15, MORF4L1, MRG15, FWP006, HSPC008, HSPC061, PP368, Eaf3, MEAF3, S863-6, HsT17725, MORFRG15.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMAPKQD PKPKFQEGER VLCFHGPLLY EAKCVKVAIK DKQVKYFIHY SGWNKNWDEW VPESRVLKYV DTNLQKQREL QKANQEQYAE GKMRGAAPGK KTSGLQQKNV EVKTKKNKQK TPGNGDGGST SETPQPPRKK RARVDPTVEN EETFMNRVEV KVKIPEELKP WLVDDWDLIT RQKQLFYLPA KKNVDSILED YANYKKSRGN TDNKEYAVNE VVAGIKEYFN VMLGTQLLYK FERPQYAEIL ADHPDAPMSQ VYGAPHLLRL FVRIGAMLAY TPLDEKSLAL LLNYLHDFLK YLAKNSATLF SASDYEVAPP EYHRKAV.

Product Science Overview

Introduction

Mortality Factor 4 Like 1 (MORF4L1), also known as MRG15, is a protein-coding gene that plays a crucial role in various cellular processes, including chromatin organization, transcriptional regulation, and DNA repair. This protein is part of several histone-modifying complexes, such as the NuA4 histone acetyltransferase (HAT) complex, histone deacetylase (HDAC) complexes, and the JARID1A and JARID1B histone demethylase complexes .

Structure and Function

MORF4L1 is a chromo domain-containing protein that recognizes di- or trimethylated lysine 36 of histone H3 through its chromo domain . This recognition is essential for its role in transcriptional regulation and chromatin remodeling. The protein is involved in the acetylation of nucleosomal histones H4 and H2A, which can alter nucleosome-DNA interactions and promote the interaction of modified histones with other proteins that positively regulate transcription .

Biological Significance

MORF4L1 is implicated in several critical cellular processes:

  • Transcriptional Activation: It is involved in the transcriptional activation of select genes, particularly those associated with oncogene and proto-oncogene-mediated growth induction, tumor suppressor-mediated growth arrest, replicative senescence, apoptosis, and DNA repair .
  • DNA Repair: The NuA4 complex, of which MORF4L1 is a part, plays a direct role in DNA repair when recruited to sites of DNA damage .
  • Histone Modification: MORF4L1 is part of complexes that modify histones, thereby influencing chromatin structure and gene expression .
Clinical Relevance

Mutations or dysregulation of MORF4L1 have been associated with various diseases, including paraneoplastic cerebellar degeneration and retinoblastoma . Understanding the function and regulation of MORF4L1 can provide insights into the mechanisms underlying these diseases and potentially lead to the development of targeted therapies.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

Related Products

MORF4L2 Human
Mortality Factor 4 Like 2 Human Recombinant
Cat. No.
BT14297
Source
Escherichia Coli.
THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.