MOG
Greater than 98.0% as determined by RP-HPLC.
Description
Myelin Oligodendrocyte Glycoprotein is a single, non-glycosylated polypeptide chain containing 21 amino acids and having a molecular mass of 2581 Dalton, the molecular formula: C118H177N35O29S.
Product Specs
H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH.
Product Science Overview
In humans, the MOG gene is located on chromosome 6 (6p22.1), while in mice, it is found on chromosome 17 . The gene was first sequenced in 1995 . The protein encoded by this gene is highly conserved across species, including humans, rats, mice, and bovines, indicating its significant biological role .
While the precise molecular function of MOG is not fully understood, it is believed to be essential for the myelination of nerves in the CNS . MOG is speculated to serve as an adhesion molecule, providing structural integrity to the myelin sheath . It is also thought to play a role in myelin maturation, myelin integrity, and cell surface interactions .
MOG has gained attention due to its involvement in inflammatory demyelinating diseases. One such condition is Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), a rare inflammatory disease where the immune system mistakenly attacks the myelin sheath . This disease affects the optic nerves, brain, and spinal cord, leading to various neurological symptoms .
Research into MOG and its associated diseases is ongoing. Understanding the role of MOG in the CNS and its involvement in demyelinating diseases could lead to better diagnostic and therapeutic strategies. The protein’s high conservation across species makes it a valuable target for studying myelination and developing treatments for related disorders .
