MOG Antibody
Description
Product Specs
Product Science Overview
Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein that plays a crucial role in the central nervous system (CNS). It is primarily found on the outermost surface of myelin sheaths and oligodendrocyte membranes. MOG is a minor component of myelin, but it is highly immunogenic and has been implicated in various demyelinating diseases, including multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) .
MOG is a member of the immunoglobulin superfamily and is encoded by the MOG gene located on chromosome 6 in humans and chromosome 17 in mice . The protein is believed to be involved in the completion and maintenance of the myelin sheath, providing structural integrity and possibly acting as a cell adhesion molecule . Despite its minor presence in myelin, MOG’s role is significant in maintaining the stability and function of the myelin sheath.
MOG is highly immunogenic, making it a target for autoimmune responses. The presence of MOG antibodies has been associated with various demyelinating diseases. In particular, MOGAD is characterized by attacks of immune-mediated demyelination predominantly targeting the optic nerves, brain, and spinal cord . MOG antibodies are detected using cell-based assays, and their presence helps distinguish MOGAD from other demyelinating diseases such as MS and neuromyelitis optica spectrum disorder (NMOSD) .
Mouse antibodies against MOG have been extensively used in research to study the pathophysiology of demyelinating diseases. One of the well-known mouse monoclonal antibodies is 8-18C5, which specifically targets MOG and has been used to induce experimental autoimmune encephalomyelitis (EAE) in animal models . These antibodies have been critical in understanding the immune response to MOG and the mechanisms underlying demyelination.
Mouse antibodies against MOG are valuable tools in both basic and clinical research. They are used to investigate the role of MOG in myelin formation, maintenance, and immune interactions. Additionally, these antibodies are employed in diagnostic assays to detect MOG antibodies in patients with demyelinating diseases, aiding in the diagnosis and differentiation of conditions like MOGAD .
