TPPP3 Human
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Description
Product Specs
MGSSHHHHHH SSGLVPRGSH MGSMAASTDM AGLEESFRKF AIHGDPKASG QEMNGKNWAK LCKDCKVADG KSVTGTDVDI VFSKVKGKSA RVINYEEFKK ALEELATKRF KGKSKEEAFD AICQLVAGKE PANVGVTKAK TGGAVDRLTD TSRYTGSHKE RFDESGKGKG IAGRQDILDD SGYVSAYKNA GTYDAKVKK
Product Science Overview
TPPP3 is a protein-coding gene that enables tubulin binding activity. It is involved in microtubule bundle formation and decidualization, which is the process by which the endometrial cells undergo structural and functional changes to support pregnancy . The protein colocalizes with microtubule bundles and the perinuclear region of the cytoplasm .
TPPP3 has been associated with various diseases, including Creutzfeldt-Jakob Disease and Dementia . It has also been studied in the context of cancer. For instance, overexpression of TPPP3 has been shown to inhibit cell proliferation and invasion in nasopharyngeal carcinoma (NPC) cells . This suggests that TPPP3 may act as an antioncogene, playing a significant role in the occurrence and progression of NPC .
Research has demonstrated that TPPP3 is a specific marker of the developing musculoskeletal system through its role in inducing tubulin polymerization . Its expression is increased in lung cancer and/or chronic obstructive pulmonary disease (COPD) groups, indicating its potential as a target for early diagnosis of lung cancer .
