LECT2 Human
Description
Product Specs
To prepare a working stock solution, it is recommended to reconstitute the lyophilized pellet in deionized water to a concentration of approximately 0.5mg/ml. Ensure complete dissolution. Please note that LECT2 is not sterile; it is essential to filter the product through a sterile filter before introducing it into cell cultures.
Product Science Overview
LECT2 was discovered during a search for novel biomarkers of inflammatory diseases . It is a 16-kDa secretory protein, also known as chondromodulin II, due to its role in promoting chondrocyte proteoglycan synthesis and cartilage growth . The protein is mainly produced in the liver but is also secreted by various other cells, including neurons, epithelial cells, parathyroid cells, and white blood cells .
LECT2 has several important functions in the human body, including:
- Liver Regeneration: It plays a crucial role in liver regeneration and repair .
- Immune Modulation: LECT2 modulates immune responses and has been shown to act as an antiviral regulator by promoting the RIG-I-mediated innate immune response .
- Bone Growth: It is involved in bone growth and development .
- Glucose Metabolism: LECT2 has a role in glucose metabolism and is associated with metabolic syndrome .
- Cancer: Dysregulation of LECT2 is linked to various cancers, including non-small cell lung cancer .
- Amyloidosis: It is implicated in renal amyloidosis and other amyloid-related diseases .
LECT2 exerts its effects through various mechanisms. For instance, it acts as a ligand for the MET receptor tyrosine kinase, promoting the recruitment of the phosphatase PTP4A1 to MET and facilitating the dissociation and dephosphorylation of phosphorylated SHP2 from MET . This process protects RIG-I from SHP2/c-Cbl-mediated degradation, enhancing the innate immune response .
