SEPT3 Human

Septin-3 is a member of the septin family of GTPases, which are cytoskeletal proteins involved in various cellular processes. These proteins are known for their ability to form filaments and play crucial roles in cell division, cellular polarization, morphogenesis, and membrane trafficking .

The septin family consists of several proteins that are essential for cytokinesis, the process by which a cell divides its cytoplasm to produce two daughter cells. Septins are also involved in maintaining cell shape, ensuring proper cell compartmentalization, and facilitating intracellular transport .

Septin-3, in particular, has been identified as a novel autoantibody target in patients with paraneoplastic cerebellar syndromes. This discovery was made through immunoprecipitation and mass spectrometry techniques, which revealed that septin-3, along with other septins, is a candidate target antigen in these patients .

Human recombinant Septin-3 is produced using recombinant DNA technology, where the gene encoding Septin-3 is inserted into a suitable expression system, such as HEK293 cells. This allows for the production of large quantities of the protein for research and therapeutic purposes .

Autoantibodies against Septin-3 have been associated with paraneoplastic cerebellar ataxia, a condition where the immune system mistakenly attacks the cerebellum, leading to coordination and balance issues. The identification of Septin-3 as an autoantibody target provides valuable insights into the pathogenesis of this condition and opens up potential avenues for diagnostic and therapeutic interventions .