HN1 Human
Hematological And Neurological Expressed 1 Human Recombinant
Cat. No.
BT19548
Source
E.coli.
Synonyms
ARM2, HN1A, Hematological and neurological expressed 1 protein, Androgen-regulated protein 2, HN1.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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In Stock 
Description
HN1 Human Recombinant produced in E. coli is a single polypeptide chain containing 174 amino acids (1-154) and having a molecular mass of 18.1kDa. HN1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Hematological and neurological expressed 1 protein (HN1) is a highly conserved protein found across various species. It plays a role in neural tissue regeneration, as evidenced by its increased expression in damaged nerve cells. HN1 is also present during embryonic development and in areas of the adult brain associated with adaptability.
Description
This recombinant HN1 protein is produced in E. coli and consists of a single chain of 174 amino acids (specifically, amino acids 1 to 154 of the human HN1 sequence), resulting in a molecular weight of 18.1kDa. For purification and detection purposes, a 20 amino acid His-tag is attached to the protein's N-terminus. The protein is purified using specialized chromatographic methods.
Physical Appearance
Clear and sterile solution.
Formulation
The HN1 protein is provided at a concentration of 0.5mg/ml in a solution containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, and 10% glycerol.
Stability
For short-term storage (up to 4 weeks), keep the protein at 4°C. For longer periods, freeze the protein at -20°C. Adding a carrier protein like HSA or BSA (0.1%) is recommended for long-term storage. Avoid repeated freezing and thawing.
Purity
The purity of this protein is greater than 90% as determined by SDS-PAGE analysis.
Synonyms
ARM2, HN1A, Hematological and neurological expressed 1 protein, Androgen-regulated protein 2, HN1.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MTTTTTFKGV DPNSRNSSRV LRPPGGGSNF SLGFDEPTEQ PVRKNKMASN IFGTPEENQA SWAKSAGAKS SGGREDLESS GLQRRNSSEA SSGDFLDLKG EGDIHENVDT DLPGSLGQSE EKPVPAAPVP SPVAPAPVPS RRNPPGGKSS LVLG.
Product Science Overview
Expression and Function
HN1 expression is upregulated in regenerating neural tissues, such as the axotomized adult rodent facial motor nerve and dedifferentiating retinal pigment epithelial cells of the Japanese newt . It is also expressed in numerous tissues during embryonic development and in regions of the adult brain that exhibit high plasticity .
Role in Tumorigenesis
Recombinant Human HN1 Protein
Recombinant human HN1 protein is produced using Escherichia coli (E. coli) as the expression system. The recombinant protein is fused to a His-tag at the N-terminus and corresponds to the amino acids 1-154 of human HN1 . The protein is purified using conventional chromatography techniques and has a purity of over 90% as determined by SDS-PAGE .
Applications
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