MAGEA6 Human

Melanoma Antigen Family A, 6 Human Recombinant

Cat. No.

BT6384

Source

E.coli.

Synonyms

Melanoma-associated antigen 6, Cancer/testis antigen 1.6, CT1.6, MAGE-6 antigen, MAGE3B antigen, MAGEA6, MAGE6, MAGE3B, MAGE-3b.

Appearance

Sterile Filtered colorless solution.

Purity

Greater than 90% as determined by SDS-PAGE.

Usage

THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

MAGEA6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 322 amino acids (1-314 a.a) and having a molecular mass of 35.9kDa.
MAGEA6 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction

MAGEA6, a member of the MAGEA family, plays a crucial role in the expression of tumor antigens recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma cells. The MAGEA family proteins share 50-80% sequence identity and are encoded by genes clustered at chromosomal location Xq28. Initially isolated from various tumors, MAGE genes are considered potential targets for cancer immunotherapy due to their nearly exclusive tumor-specific expression in adult tissues. The significant variability observed in the promoters and first exons of MAGEA genes suggests that this gene family allows for the expression of a common function under diverse transcriptional control. Notably, MAGEA genes have been implicated in several hereditary disorders, including dyskeratosis congenita.

Description

Recombinant MAGEA6, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 322 amino acids (1-314 a.a.) with a molecular mass of 35.9 kDa. It includes an 8 amino acid His-tag at the C-terminus and is purified using proprietary chromatographic techniques.

Physical Appearance

A clear, colorless solution that has been sterilized by filtration.

Formulation

The MAGEA6 protein solution (1 mg/ml) is supplied in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.1 M NaCl, 10% glycerol, and 1 mM DTT.

Stability

For short-term storage (up to 4 weeks), keep refrigerated at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.

Purity

The purity is determined to be greater than 90% using SDS-PAGE analysis.

Synonyms

Melanoma-associated antigen 6, Cancer/testis antigen 1.6, CT1.6, MAGE-6 antigen, MAGE3B antigen, MAGEA6, MAGE6, MAGE3B, MAGE-3b.

Source

E.coli.

Amino Acid Sequence

MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAKLVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASDSLQL VFGIELMEVD PIGHVYIFAT
CLGLSYDGLL GDNQIMPKTG FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG DPKKLLTQYF VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS YPLLHEWALR EGEELEHHHH HH.

Product Science Overview

Introduction

The Melanoma Antigen Family A (MAGE-A) is a group of proteins that belong to the larger family of cancer/testis (CT) antigens. These antigens are characterized by their restricted expression in immune-privileged tissues, such as the testis, and a variety of cancers. MAGE-A proteins have gained significant attention in cancer research due to their potential as biomarkers and therapeutic targets.

Discovery and Classification

The MAGE-A family was first identified in the early 1990s when researchers were searching for tumor-associated antigens. MAGE-A1 was the first member discovered, and subsequent studies identified more proteins with similar properties. The MAGE-A family consists of over 60 proteins, which are further subdivided into two groups based on the location of their genes.

Structure and Function

MAGE-A proteins share a common MAGE homology domain, which is crucial for their function. These proteins are typically presented on the cell surface by major histocompatibility complex (MHC) class I molecules, making them accessible to the immune system. The primary function of MAGE-A proteins is to promote cell survival and proliferation, which is why their expression is often associated with cancer.

Melanoma Antigen Family A, 6 (MAGE-A6)

MAGE-A6 is one of the members of the MAGE-A family. Like other MAGE-A proteins, MAGE-A6 is expressed in various cancers, including melanoma, bladder cancer, and others. Its expression is usually restricted to cancerous tissues and not found in normal tissues, except for the testis. This restricted expression pattern makes MAGE-A6 an attractive target for cancer immunotherapy.

Therapeutic Potential

The unique expression pattern of MAGE-A6 and other MAGE-A proteins has made them promising candidates for cancer immunotherapy. Several strategies are being explored to target these proteins, including cancer vaccines, adoptive T-cell transfer, and combination therapies. These approaches aim to harness the immune system to recognize and destroy cancer cells expressing MAGE-A6.

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MAGEA6 Human

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