MAGEB10 Human

Melanoma Antigen Family B,10 Human Recombinant
Cat. No.
BT6534
Source
Escherichia Coli.
Synonyms
Melanoma Antigen Family B,10, MAGE-B10 Antigen, MAGE Family Testis And Tumor-Specific Protein, Melanoma-Associated Antigen B10, MAGE-B10 antigen.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

MAGEB10 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids (1-347 a.a) and having a molecular mass of 41.4kDa.
MAGEB10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Melanoma Antigen Family B,10, also known as MAGEB10, is a protein belonging to the B subfamily of melanoma-associated antigens. Its expression is primarily observed in testicular and cancerous cells. Notably, MAGEB10 has been linked to melanoma.
Description
Recombinant human MAGEB10, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 370 amino acids (residues 1-347) with a molecular weight of 41.4 kDa. It includes a 23-amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear solution, sterilized by filtration.
Formulation
MAGEB10 protein solution (0.25 mg/ml) in a buffer of 20 mM Tris-HCl (pH 8.0), 0.15 M NaCl, 10% glycerol, 1 mM DTT, and 0.1 mM PMSF.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended periods, store frozen at -20°C. Adding a carrier protein like 0.1% HSA or BSA is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 85%, as determined by SDS-PAGE analysis.
Synonyms
Melanoma Antigen Family B,10, MAGE-B10 Antigen, MAGE Family Testis And Tumor-Specific Protein, Melanoma-Associated Antigen B10, MAGE-B10 antigen.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPRGQKS KLRAREKRRQ ARGGLEDLID ALDILEEEEE SPPSASACLK DVFQSSLDGA SNNPHGLREA QSTSTSATAA SHTRHPEGVN DQMEERPICT QDLEATDSFP RGPVDEKVII LVHYLLYKYQ MKEPITKADM LRNVTQMSKS QFPVILSRAS EHLELIFGLD LKEVEPNKHI YVLVNKLDLG CDAKLSDETG VPKTGLLMTV LGIIFTNGNC VAEEEVWKVF NTMGLYDGIE HFMFGEPRKL LTKDLVKENY LEYQQVPNSD PPRYQFLWGP RAHAETSKMK VLEFLAKVND TAPSEFSNWY TEALQDEEER ARARVAAKAR VSATAGARSK VKSSKSSQLQ

Product Science Overview

Introduction

Melanoma Antigen Family B,10 (MAGE-B10) is a member of the MAGE (Melanoma Antigen Gene) family, which is known for its role in cancer immunotherapy. These antigens are typically expressed in various types of tumors, including melanoma, and are recognized by the immune system, making them potential targets for cancer treatment.

Gene and Protein Structure

The MAGE family consists of several subfamilies, including MAGE-A, MAGE-B, and MAGE-C, all of which are located on the X chromosome . MAGE-B10, specifically, is part of the MAGE-B subfamily. The genes in this family encode proteins that are involved in various cellular processes, including cell cycle regulation and apoptosis.

Expression and Function

MAGE-B10 is predominantly expressed in male germline cells and various tumors but is not typically found in normal tissues . This restricted expression pattern makes it an attractive target for cancer immunotherapy, as targeting MAGE-B10 can potentially minimize damage to normal cells while attacking cancer cells.

Role in Cancer Immunotherapy

The MAGE family, including MAGE-B10, has been extensively studied for its potential in cancer immunotherapy. These antigens can be recognized by cytotoxic T lymphocytes (CTLs), which can then target and destroy the tumor cells expressing these antigens . This has led to the development of various therapeutic strategies, including cancer vaccines and adoptive T cell therapies, aimed at enhancing the immune response against tumors expressing MAGE antigens.

Recombinant MAGE-B10

Recombinant MAGE-B10 refers to the artificially synthesized version of the MAGE-B10 protein. This recombinant protein can be used in research and therapeutic applications. For instance, it can be employed to study the immune response to MAGE-B10 or to develop cancer vaccines that stimulate the immune system to target tumors expressing this antigen.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.