TRAPPC3 Human

TRAPPC3 is involved in the tethering of transport vesicles to the cis-Golgi membrane. This process is essential for the proper functioning of the secretory pathway, which is responsible for the transport and modification of proteins and lipids within the cell . The TRAPP complex, including TRAPPC3, ensures that vesicles are accurately targeted and fused with the correct membrane compartments, facilitating efficient intracellular transport .

The TRAPPC3 gene is located on chromosome 1 and is a protein-coding gene. It has been associated with several diseases, including Primary Ciliary Dyskinesia and Senior-Loken Syndrome . The gene undergoes alternative splicing, resulting in multiple transcript variants that encode different protein isoforms .

TRAPPC3 is part of several critical cellular pathways, including:

• Transport to the Golgi and subsequent modification: This pathway involves the movement of proteins and lipids from the ER to the Golgi apparatus, where they undergo further modifications .
• Vesicle-mediated transport: This pathway encompasses the formation, movement, and fusion of vesicles within the cell, ensuring the proper distribution of cellular components .

Research on TRAPPC3 has highlighted its importance in maintaining cellular homeostasis and its potential implications in various diseases. Mutations or dysregulation of TRAPPC3 can lead to defects in vesicular transport, contributing to the development of certain genetic disorders .